A small-molecule TNIK inhibitor targets fibrosis in ... - Nature
Mar 8, 2024 · We identify TRAF2- and NCK-interacting kinase (TNIK) as an anti-fibrotic target using a predictive artificial intelligence (AI) approach.
TNIK’s emerging role in cancer, metabolism, and age-related …
May 21, 2024 · Traf2- and Nck-interacting kinase (TNIK) has emerged as a key regulator of pathological metabolic signaling in several diseases and is a promising drug target. Originally studied for its role in cell migration and proliferation, TNIK possesses several newly identified functions that drive the pathogenesis of multiple diseases.
TNIK is a conserved regulator of glucose and lipid metabolism in …
Aug 9, 2023 · The concept that TNIK/msn is sensitive to glucose, and likely at the junction of lipid metabolism, opens perspectives for investigations on metabolic regulation of TNIK in obesity and T2D and eventually therapeutic targeting of TNIK signaling.
TNIK - Wikipedia
TNIK has been shown to phosphorylate Gelsolin, a protein involved in F-actin depolymerisation thus inducing cytoskeletal changes. [6] TNIK plays an important role in pulmonary fibrosis. Inhibitors of TNIK are used in the treatment of pulmonary fibrosis.
TNIK signaling imprints CD8+ T cell memory formation early after ...
Apr 2, 2020 · These findings reveal that TNIK is an important regulator of effector and memory T cell differentiation and induces a population of stem cell-like memory T cells.
TNIK Gene - GeneCards | TNIK Protein | TNIK Antibody
Oct 2, 2024 · TNIK (TRAF2 And NCK Interacting Kinase) is a Protein Coding gene. Diseases associated with TNIK include Intellectual Developmental Disorder, Autosomal Recessive 54 and Autosomal Recessive Non-Syndromic Intellectual Disability. Among its related pathways are Cellular responses to stimuli and Cellular Senescence.
TNIK in disease: from molecular insights to therapeutic prospects
Jun 9, 2024 · TRAF2 and NCK interacting kinase (TNIK), a critical interacting protein kinase, is currently receiving wide attention. TNIK is found in various human body organs and tissues and participates in cell motility, proliferation, and differentiation.
TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways …
Toward these issues, we were intrigued by Traf2 and NcK interacting kinase (TNiK), a protein with both scaffolding and kinase domains that had been implicated in postsynaptic signaling as well as in regulation of cell proliferation (Mahmoudi et al., 2009; Shitashige et al., 2010). TNiK is expressed in the nervous system but its role in vivo is ...
TNIK TRAF2 and NCK interacting kinase [ (human)] - National …
Sep 19, 2024 · TNIK is required for the tumour-initiating function of colorectal cancer stem cells. Its inhibition is a promising therapeutic approach. Results indicate that Traf2- and Nck-interacting kinase (TNIK) is involved in the interleukin-6-dependent proliferation of multiple myeloma cells.
TNIK Inhibition Has Dual Synergistic Effects on Tumor and …
Kim et al. reports dual synergistic effects of TNIK inhibition on tumor and associated immune cells. TNIK inhibition increased tumor infiltration of PD-1 + CD8 + T cells, thus contributing to tumor control.