Toll-like receptor 3-elicited MAPK activation induces ... - PubMed
Chemical inhibition of p38 and MK2, and siRNA knockdown of MK2 relieved dsRNA-triggered prolongation of IFN-β mRNA half-life. Taken together, these results suggest that TLR3 induces …
Targeting mast cell activation alleviates anti-MHC I antibody and …
Nov 1, 2024 · Pharmacologically targeting the TLR3/MAPK pathway to inhibit mast cell activation normalizes the proinflammatory microenvironment and alleviates lung inflammation and injury …
Toll-like receptor 3 (TLR3) regulation mechanisms and roles in ...
Phosphoinositide 3-kinase (PI3K), p38-mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK) are also activated by TLR3 …
MAPK通路（上游部分） - 知乎专栏
TAK1，转化生长因子激酶1，是MAP3K家族的成员，它可以激活经典IκB激酶（IKK）复合物和促分裂原活化蛋白激酶的激酶（MKK），MKK激活p38 MAP激酶和c-Jun氨基末端激酶1 …
p38 MAPK activation controls the TLR3-mediated up-regulation …
Dec 15, 2004 · In accordance with the expression of Toll-like receptor-3 (TLR3) and of TRIF/TICAM-1 adaptor, poly I:C stimulation induces the activation of interferon regulatory …
Toll-like receptor 3-elicited MAPK activation induces stabilization …
Mar 1, 2012 · We wanted to determine if p38 MAPK and MK2 were activated downstream of TLR3/TRIF and contributed to stabilization of IFN-β mRNA. TLR3-HEK293 cells were treated …
Glycogen synthase kinase 3β ubiquitination by TRAF6 regulates TLR3 …
Apr 1, 2015 · In this report, we show that GSK3β is essential for TLR3-mediated ERK and p38 activation, c-Fos induction and pro-inflammatory cytokine production. We also find that GSK3β …
A Critical Role for MAPK Signalling Pathways in the Transcriptional ...
Feb 6, 2013 · Data demonstrated a consistent role for elements of the MAPK pathway (p38, MEK and JNK) in agonist-dependent regulation of cognate TLR mRNA levels. LPS consistently and …
一文带你完全了解Toll样受体（二）——通路 - 丁香园论坛
MyD88是TIR家族中第一个被发现的成员，除TLR3外，所有的TLR都普遍使用MyD88，它能激活转录因子NF-κB和丝裂原激活的蛋白激酶 (MAPK)来诱导炎性细胞因子。 相反，TRIF被TLR3 …
MAPK/p38 regulation of cytoskeleton rearrangement accelerates ... - PubMed
Toll-like receptor 3 (TLR3) and TLR4 utilize adaptor proteins to activate mitogen‑activated protein kinase (MAPK), resulting in the acute but transient inflammatory response aimed at the …