Thyroid hormone receptor beta: Relevance in human health and …
Dec 1, 2023 · Recent evidences reveal the direct association of THR with different gonadal hormone receptors, i.e., androgen receptor, estrogen receptor, progesterone receptor, etc., to regulate reproduction physiology (Kakita-Kobayashi et al., 2020; Ren and Zhu, 2022).
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New ...
A lack of thyroid hormones is not compatible with normal health. Most THs effects are mediated by two different thyroid hormone receptor (TR) isoforms, namely TRα and TRβ, with the TRβ isoform known to be responsible for the main beneficial effects of TH on liver.
Resistance to Thyroid Hormone Beta: A Focused Review - PMC
Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity to thyroid hormone (TH) and its more common form is caused by mutations in the thyroid hormone receptor beta (THRB) gene, termed RTHβ.
Thyroid Hormone Receptor Beta - an overview - ScienceDirect
Thyroid Hormone Receptor Beta (TR-β) is a nuclear receptor that binds to thyroid hormone and plays a crucial role in regulating gene expression in various organs such as the liver, kidney, and thyroid.
THRB Gene - GeneCards | THB Protein | THB Antibody
Dec 25, 2024 · THRB (Thyroid Hormone Receptor Beta) is a Protein Coding gene. Diseases associated with THRB include Thyroid Hormone Resistance, Generalized, Autosomal Dominant and Thyroid Hormone Resistance, Selective Pituitary. Among its related pathways are Gene expression (Transcription) and Nuclear receptors.
Thyroid hormone receptor localization in target tissues - PMC
The thyroid hormone receptors, TRα1, TRβ1, and other subtypes, are members of the nuclear receptor superfamily that mediate the action of thyroid hormone signaling in numerous tissues to regulate important physiological and developmental processes.
The thyroid hormone receptor beta gene: structure and ... - PubMed
The thyroid hormone receptor beta gene (Thrb) is a key mediator of many of these actions. The Thrb gene is complex, spanning up to 400 kb in mammals, and differentially expresses distinct receptor subtypes through independent tissue-specific promoters and alternative splicing.
Thyroid Hormone Receptor Beta - an overview - ScienceDirect
Thyroid hormone receptor (TR)-β forms the basic transcriptional complex with retinoic acid receptor (RXR) in the presence of T3, co-activators bind to the TRβ/RXR complex, to mediate gene expression. In the absence of triiodothyronine (T3), co-repressors bind to the TRβ/RXR complex to repress gene transcription.
Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New ... - PubMed
Jul 9, 2020 · Most THs effects are mediated by two different thyroid hormone receptor (TR) isoforms, namely TRα and TRβ, with the TRβ isoform known to be responsible for the main beneficial effects of TH on liver. In brain, despite the crucial role of TRα isoform in neuronal development, TRβ has been proposed to play a role in the remyelination processes.
7068 - Gene ResultTHRB thyroid hormone receptor beta
Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome. Life Without Thyroid Hormone Receptor. Structural insights revealed by two novel THRB mutations.
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