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    Wikipedia
    https://en.wikipedia.org/wiki/Tioguanine

    Tioguanine - Wikipedia

    Tioguanine, also known as thioguanine or 6-thioguanine (6-TG) or tabloid is a medication used to treat acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and chronic myeloid leukemia (CML). Long-term use is not recommended. It is given by mouth. Common side effects include … See more

    Medical uses

    • Acute leukemias in both adults and children
    • Chronic myelogenous leukemia
    • See more

    Side effects

    • Leukopenia and neutropenia
    • Thrombocytopenia
    • Anemia
    • See more

    Interactions

    Cancers that do not respond to treatment with mercaptopurine do not respond to thioguanine. On the other hand, some cases of IBD that are … See more

    Metabolism and pharmacokinetics

    A single oral dose of thioguanine has incomplete metabolism, absorption and high interindividual variability. The bioavailability of thioguanine has an average of 30% … See more

    Mechanism of action

    6-Thioguanine is a thio analogue of the naturally occurring purine base guanine. 6-thioguanine utilises the enzyme See more

    Overview image
    Contraindications

    • Pregnancy
    • Lactation: The safety warning against breastfeeding may have been a conservative assessment, but research evidence suggests that thiopurines do not enter breastmilk. See more

    Pharmacogenetics

    The enzyme thiopurine S-methyltransferase (TPMT) is responsible for the direct inactivation of thioguanine to its methylthioguanine base – this methylation prevents … See more

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    Pharmacogenetics
    Metabolism and pharmacokinetics
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  2. Images of Thioguanin

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  3. Drugs.com
    https://www.drugs.com/mtm/thioguanine.html

    Thioguanine Uses, Side Effects & Warnings - Drugs.com

  4. Mayo Clinic
    https://www.mayoclinic.org/drugs-supplements/thio...

    Thioguanine (oral route) - Mayo Clinic

  5. MedlinePlus
    https://medlineplus.gov/druginfo/meds/a…

    Thioguanine: MedlinePlus Drug Information

    Thioguanine is used to treat acute myeloid leukemia (AML; a type of cancer that begins in the white blood cells). Thioguanine is in a class of medications known as purine analogs. It works by slowing or stopping the growth of cancer cells …

  6. WebMD
    https://www.webmd.com/drugs/2/drug-14103/thioguanine-oral/details

    Thioguanine Tablet - Uses, Side Effects, and More - WebMD

  7. Medicine.com
    https://www.medicine.com/drug/thioguanine/hcp

    Thioguanine: Dosage, Mechanism/Onset of Action, Half-Life

  8. People also ask
    What is thioguanine used for?
    Medically reviewed by Drugs.com on Apr 11, 2024. Written by Cerner Multum. What is thioguanine? Thioguanine is used to treat acute nonlymphocytic leukemia (a type of blood cancer), sometimes in combination with other cancer medicines. Thioguanine may also be used for purposes not listed in this medication guide.

    Thioguanine Uses, Side Effects & Warnings - Drugs.com

    drugs.com
    Is thioguanine FDA approved?
    FDA label information for this drug is available at DailyMed. Thioguanine is approved to be used as remission induction therapy and remission consolidation therapy to treat: Acute myeloid leukemia (AML). Thioguanine is also being studied in the treatment of other types of cancer.

    Thioguanine - NCI - National Cancer Institute

    cancer.gov
    Can thioguanine be used long-term?
    Long-term/maintenance treatment with thioguanine is not recommended. Advise patients to avoid alcohol; may increase the risk for hepatotoxicity. Photosensitivity: Thioguanine may cause photosensitivity; sunscreen and protective clothing are recommended. Secondary malignancies: Thioguanine is potentially carcinogenic.

    Thioguanine: Dosage, Mechanism/Onset of Action, Half-Life - Medicine.…

    medicine.com
    Where can I find information about thioguanine?
    This page contains brief information about thioguanine and a collection of links to more information about the use of this drug, research results, and ongoing clinical trials. FDA label information for this drug is available at DailyMed.

    Thioguanine - NCI - National Cancer Institute

    cancer.gov
    How is thioguanine excreted?
    Thioguanine is excreted primarily through the kidneys in urine, but mainly as a metabolite, 2-amino-6-methylthiopurine. However, the intra-cellular thio-nucleotide metabolites of thioguanine (6-TGN) have longer half-lives and can therefore be measured after thioguanine is eliminated from the plasma.

    Tioguanine - Wikipedia

    en.wikipedia.org
    What is the bioavailability of thioguanine?
    The bioavailability of thioguanine has an average of 30% (range 14-46%). The maximum concentration in plasma after a single oral dose is attained after 8 hours. Thioguanine, like other thiopurines, is cytotoxic to white cells; as a result it is immunosuppressive at lower doses and anti-leukemic/anti-neoplastic at higher doses.

    Tioguanine - Wikipedia

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  9. DrugBank Online
    https://go.drugbank.com/drugs/DB00352

    Tioguanine: Uses, Interactions, Mechanism of Action

    427 rows · Jun 13, 2005 · Thioguanine is an antineoplastic anti-metabolite used in the treatment of several forms of leukemia including acute nonlymphocytic leukemia. Anti-metabolites masquerade as purine or …

  10. Cancer.gov
    https://www.cancer.gov/about-cancer/treatment/drugs/thioguanine

    Thioguanine - NCI - National Cancer Institute

  11. MedicineNet
    https://www.medicinenet.com/thioguanine-oral/article.htm

    THIOGUANINE - ORAL side effects, medical uses, and drug

  12. Patient
    https://patient.info/medicine/tioguanine

    Tioguanine - Treatment of AML, ALL & CML. Leukaemia drugs