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  1. Studies of Th2 Cells
    PubMed
    TH2 cell development and function
    T helper 2 (TH2) cells orchestrate protective type 2 immune responses, such as those that target helminths and facilitate tissue repair, but also contribute to chronic inflammatory diseases, such as asthma and allergy. Here, we review recent insights
    Author: Jennifer A Wal…
    Published: 2018/2
    Keywords: National In…
    National Center for Biotechnology Information
    Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
    Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses. Emerging evidence
    Author: Kota Kokubo, …
    Published: 2022
    Publication: Front Imm…
    PubMed
    Th2 Cells in Health and Disease
    Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2 cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection from helminth infection and are central to the pathogenesis of many
    Author: Toshinori Nak…
    Published: 2017/04/26
    Keywords: Gata3; Pol…
    National Center for Biotechnology Information
    Molecular Mechanisms of T Helper Cell Differentiation and Functional Specialization
    Th cells, which orchestrate immune responses to various pathogens, differentiate from naïve CD4 T cells into several subsets that stimulate and regulate immune responses against various types of pathogens, as well as a variety of immune-related diseases.
    Author: Gap Ryol Lee
    Published: 2023/02
    Publication: Immune …
    National Center for Biotechnology Information
    T helper 2 and T follicular helper cells: Regulation and Function of Interleukin-4
    Type 2 immunity is characterized by expression of the cytokines interleukin (IL)-4, IL-5, IL-9 and IL-13, which can function in mediating protective immunity in the host or possess a pathogenic role. T helper (Th) 2 cells have emerged to play a beneficial
    Author: Anupama Sah…
    Published: 2016/08
    DOI: 10.1016/j.cytogfr.…
    PubMed
    Current understanding of Th2 cell differentiation and function
    Helper T cell (Th) has been identified as a critical immune cell for regulating immune response since 1980s. The type 2 helper Tcell (Th2), characterized by the production of interleukin-4 (IL-4), IL-5 and IL-13, plays a critical role in immune response
    Author: Zhenhu Li
    Published: 2011/8
    Keywords: National In…
    National Center for Biotechnology Information
    T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
    Interleukin-4 (IL-4), IL-5 and IL-13, the signature cytokines that are produced during type 2 immune responses, are critical for protective immunity against infections of extracellular parasites and are responsible for asthma and many other allergic inflammatory
    Author: Jinfang Zhu
    Published: 2015/09
    DOI: 10.1016/j.cyto.201…
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    Wikipedia
    https://en.wikipedia.org/wiki/T_helper_cell

    T helper cell | Wikipedia

    The T helper cells (Th cells), also known as CD4 cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cell antibody class switching, breaking cross-tolerance in … See more

    Structure and function

    Th cells contain and release cytokines to aid other immune cells. Cytokines are small protein mediators that alter the behavior of target cells that express receptors for … See more

    Determination of the effector T cell response image
    Determination of the effector T cell response

    Helper T cells are capable of influencing a variety of immune cells, and the T cell response generated (including the extracellular signals … See more

    Role in disease

    Considering the diverse and important role helper T cells play in the immune system, it is not surprising that these cells often influence the immune … See more

    Overview image
    Activation of naive helper T cells image
    Activation of naive helper T cells

    Following development in the thymus, these cells (termed recent thymic emigrants (RTE)) egress from the thymus and home to secondary lymphoid organs (SLO; See more

    Effector function

    In 1991, three groups reported discovering CD154, which is the molecular basis of T cell helper function. Seth Lederman at Columbia University generated a murine monoclonal antibody, 5c8 that inhibited contact-dependent T cell helper function in human cells which … See more

    Memory T cell

    Historically, memory T cells were thought to belong to either the effector or central memory subtypes, each with their own distinguishing set of cell surface markers. Central memory T … See more

    See also

    • CD4 /CD8 ratio
    • CD4 T cells and antitumor immunity
    • CD8 T cells
    • Cancer vaccine targeting CD4 T cells
    • List of distinct cell types in the adult human body See more

    From Wikipedia
    From Wikipedia
    Content
    Structure and function
    Activation of naive helper T cells
    Effector function
    Determination of the effector T cell response
    Memory T cell
    Role in disease
    See also
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  3. Nature
    https://www.nature.com/articles/nri.2017.118

    TH2 cell development and function | Nature Reviews Immunology

  4. Images of Th2 Cells

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    frontiersin.org
    Frontiers | Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
    frontiersin.org
    Frontiers | Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis
    ajp.amjpathol.org
    Control of Th2-Mediated Inflammation by Regulatory T Cells - The American Journal of Pathology
    cell.com
    A model of Th2 differentiation based on polarizing cytokine repression: Trends in Immunology
    jlb.onlinelibrary.wiley.com
    Regulation of the T helper cell type 2 (Th2)/T regulatory cell (Treg) balance by IL‐4 and STAT6 ...
    baike.baidu.hk
    Th2細胞_百度百科
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  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29082915

    TH2 cell development and function | PubMed

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9395650

    Conventional and pathogenic Th2 cells in inflammation, tissue …

  7. PubMed
    https://pubmed.ncbi.nlm.nih.gov/27912316

    Th2 Cells in Health and Disease | PubMed

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9995992

    Molecular Mechanisms of T Helper Cell Differentiation and …

  10. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110032

    T helper 2 and T follicular helper cells: Regulation and Function of ...

  11. Nature
    https://www.nature.com/articles/nri2735

    How are TH2-type immune responses initiated and amplified?

  12. Nature
    https://www.nature.com/articles/nri.2017.118.pdf
    [PDF]

    TH2 cell development and function | Nature

  13. PubMed
    https://pubmed.ncbi.nlm.nih.gov/21904976

    Current understanding of Th2 cell differentiation and function

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