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  1. Nature
    https://www.nature.com › articles

    TXNIP: A key protein in the cellular stress response pathway and a ...

    • Thioredoxin-interacting protein (TXNIP), which is also known as thioredoxin-binding protein 2 (TBP2), directly interacts with the major antioxidant protein thioredoxin (TRX) and inhibits its antioxidant func… See more

    Introduction

    Thioredoxin interacting protein (TXNIP), which is also known as thioredoxin (TRX) binding … See more

    Nature
    Multiple functions of TXNIP in the cellular stress response pathway

    The TRX system: TXNIP regulates oxidative stress
    TXNIP is a central physiological inhibitor of the TRX redox system, and its transcription and activit… See more

    Nature
    Role of TXNIP in the pathogenesis of diseases

    Diabetes
    Diabetes is a common metabolic disorder characterized by hyperglycemia, loss of functional pancreatic β-cell mass, and insufficient … See more

    Nature
    Therapeutic potential of targeting TXNIP in diseases

    TXNIP is a key pathological regulator of several diseases, including CKD, diabetes, and neurodegenerative diseases, and is an attractive therapeutic target for the developme… See more

    Nature
    Conclusion and future perspective

    We reviewed currently available information on the roles of the multifunctional protein TXNIP in the pathogenesis of diseases such as diabetes, chronic kidney disease, and neurod… See more

    Nature
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    Table of Contents
    Introduction
    Multiple functions of TXNIP in the cellular stress response pathway
    Role of TXNIP in the pathogenesis of diseases
    Therapeutic potential of targeting TXNIP in diseases
    Conclusion and future perspective
     
  1. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    TXNIP: A Double-Edged Sword in Disease and Therapeutic Outlook

  2. Images of TRX TXNIP

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  3. Nature
    https://www.nature.com › articles

    The role of TXNIP in cancer: a fine balance between redox ... - Nature

  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    TXNIP/TBP-2: A Master Regulator for Glucose Homeostasis

  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    TXNIP: A key protein in the cellular stress response pathway

  6. Nature
    https://www.nature.com › articles

    The structural basis for the negative regulation of thioredoxin by ...

  7. FEBS Press
    https://febs.onlinelibrary.wiley.com › doi › full

    Thioredoxin‐interacting protein (TXNIP) is a substrate of the …

  8. PubMed
    https://pubmed.ncbi.nlm.nih.gov

    Thioredoxin/Txnip: redoxisome, as a redox switch for the

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    TXNIP: A key protein in the cellular stress response pathway and a ...

  10. nih.gov
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Thioredoxin-Interacting Protein (TXNIP) in Cerebrovascular and ...