Transcription factor II D - Wikipedia
Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein -coding genes in living cells.
Structure of promoter-bound TFIID and model of human pre ...
Mar 23, 2016 · The general transcription factor IID (TFIID) plays a central role in the initiation of RNA polymerase II (Pol II)-dependent transcription by nucleating pre-initiation complex (PIC)...
Recent insights into the structure of TFIID, its assembly ...
Apr 1, 2020 · TFIID is a large multiprotein assembly that serves as a general transcription factor for transcription initiation by eukaryotic RNA polymerase II (Pol II). TFIID is involved in the recognition of the core promoter sequences and neighboring chromatin marks, and can interact with gene-specific activators and repressors.
Regulation of the RNA polymerase II pre-initiation complex by ...
Aug 2, 2023 · In this Review, the authors discuss recent advances in our understanding of Mediator and TFIID, coactivators associated with the RNA polymerase II (Pol II) pre-initiation complex (PIC), focusing...
Transcription Factor IID - an overview | ScienceDirect Topics
Transcription Factor IID (TFIID) is a multi-subunit factor crucial for the initiation of transcription at RNA polymerase II-regulated genes. It consists of the TATA-binding protein (TBP) and a group of highly conserved proteins called TBP-associated factors (TAFs), playing a key role in stabilizing the transcriptional pre-initiation complex at ...
A central role for TFIID in the pluripotent transcription ...
Mar 17, 2013 · Here we show that knockdown of the transcription factor IID (TFIID) complex affects the pluripotent circuitry in mouse ES cells and inhibits reprogramming of fibroblasts. TFIID subunits and...
Promoter Recognition: Putting TFIID on the Spot - Cell Press
Jul 9, 2019 · Highlights. TFIID nucleates pol II transcription initiation via recognition of core promoters through interactions with DNA, modified histones, and transcriptional (co)activators. Most human promoters do not contain a TATA box. Other DNA elements, such as the initiator, DPE, MTE, or DCE are rare.