单细胞免疫组库VDJ——基础知识（一） - 简书
May 11, 2022 · BCR和TCR有三个高变区CDR1、CDR2、CDR3，其中以CDR3变异最大，直定了抗原结合特异性，对于B细胞和T细胞多样性的研究也就集中在CDR3 区。 图1、BCR和TCR …
TCR测序及分析方法简述 - 知乎 - 知乎专栏
T细胞介导的抗原识别取决于T细胞受体（TCR）与抗原主要组织相容性复合体（MHC）分子的相互作用。. TCR是高度多样化的异源二聚体，由大多数T细胞表达的α和β链（αβ TCR）的组 …
免疫三千问—单细胞测序之肿瘤微环境 - 知乎 - 知乎专栏
在T细胞对肿瘤抗原的识别中，CDR3是TCR测序优先选择的研究目标区域，TCR-CDR3区的特征（CDR3区的长度、序列等）研究可直接反映出T细胞多态性和克隆化程度，从而反映T细胞的 …
Machine learning identifies T cell receptor repertoire signatures ...
Jan 20, 2023 · TCR repertoire analyses from these data identify and characterize convergent COVID-19-associated CDR3 gene usages, specificity groups, and sequence patterns. Here …
DeepTCR is a deep learning framework for revealing sequence ... - Nature
Mar 11, 2021 · We present DeepTCR, a suite of unsupervised and supervised deep learning methods able to model highly complex TCR sequencing data by learning a joint representation …
Analyzing the CDR3 Repertoire with respect to TCR—Beta …
Jul 12, 2016 · We sequenced the TCR beta chain CDR3 repertoire of peripheral T cells from six healthy volunteers and six BALB/c mice and analyzed the composition and characteristics of …
DeepAIR：有效整合序列和3D结构以实现TCR分析 - 健康界
Aug 30, 2023 · 结果表明，pLDDT总体上反映了TCR CDR3结构的预测精度。使用具有不同pLDDT分数的预测CDR3结构的TCR来评估DeepAIR、DeepAIR-stru和DeepAIR-seq的AUC …
Predicting antigen specificity of single T cells based on TCR CDR3 ...
Aug 11, 2020 · Here, we describe proposed architectures of the models that predict antigen specificity of a T‐cell receptor (TCR) based on the CDR3 loop of both ɑ‐ and β‐chains and on …
Contribution of T Cell Receptor Alpha and Beta CDR3, MHC …
Historically, the main element used in TCR-peptide binding prediction was the Complementarity Determining Region 3 (CDR3) of the beta chain. However, recently the contribution of other …
The characteristics of TCR CDR3 repertoire in COVID-19 patients …
Oct 28, 2024 · T-cell receptor complementarity determining region 3 (TCR CDR3) repertoire serves as a target molecule for monitoring the effects, mechanisms, and memory of the T-cell …