Stem-loop (Hairpin loop): Properties, Types, Examples, Uses
WEBMay 15, 2024 · What is a stem-loop (hairpin loop)? A Stem-loop can be defined as a hairpin-like pattern formed because of the intramolecular base pairing of the nucleotide sequence (especially in palindromic sequence) within the same molecule.
Stem-Loop - an overview | ScienceDirect Topics
WEBAug 28, 2012 · The stem–loop structures, also called hairpins, play an important role in the tertiary folding of RNA molecules. They also serve as critical sites for the interaction with other nucleic acids and proteins.
Stem-loop oligonucleotides: a robust tool for molecular biology …
WEBJun 1, 2002 · The specific structural features of stem-loop (hairpin) DNA constructs provide increased specificity of target recognition. Recently, several robust assays have been developed that exploit the potential of structurally constrained oligonucleotides to hybridize with their cognate targets.
Metabolism and regulation of canonical histone mRNAs: life without …
WEBReplication-dependent histone mRNAs are present at high levels only in S phase cells, and in mammalian cells the stem–loop is the major cis element responsible for cell cycle regulation. SLBP is...
Stems and Loops - SpringerLink
WEBApr 28, 2016 · All types of RNA fold into highly significant (non-random) ‘stem-loop’ structures. While the selective forces affecting tRNA and rRNA structures mainly relate to their roles in the cytoplasm, those affecting mRNA structures largely relate to the need for structure (stem-loop potential) of the genes from which they were transcribed.
From Revolution to Evolution: Stem-loop Real-time PCR
WEBSep 27, 2016 · The stem-loop primer is the main ingredient that makes miRNA amplification feasible. These RT primers are highly specific because of the way they are designed. The stem-loop primer consists of a constant region that forms a stem loop and a variable six- nucleotide extension.
Chromosome Structure II: Stem-loops and Circle-loops - eLife
WEBJun 20, 2024 · Key to understanding the 3D organization of chromosomes in multicellular eukaryotes will be the identification of TADs that are stem-loops and TADs that are circle-loops. In the studies reported here, we have used MicroC to analyze the contact maps generated by stem-loops and circle-loops.
Stem-Loop - an overview | ScienceDirect Topics
WEBA stem-loop in the context of Neuroscience refers to a partially self-complementary sequence that is designed to reverse the biogenesis of microRNA. It is used in stem-loop reverse transcription to copy the mature microRNA sequence and enhance the specificity of the process.
Specific length and structure rather than high thermodynamic …
WEBFeb 21, 2022 · An mRNA stem-loop likely samples alternative conformations at the entry to mRNA tunnel. In some of these conformations, translocation and basepair unwinding might be slowed down.
Accurate detection of RNA stem-loops in structurome data reveals ...
WEBOct 4, 2021 · Application of the classifier to human structurome data reveals a marked association between detected stem-loops and RNA binding protein (RBP) footprints. The results of our application demonstrate that upwards of 30% of RBP footprints occur within loops of stable stem-loop elements.
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