The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled … See more

Due to its high tissue tropism, biotechnology companies seek to utilize modified SV40 based vectors as a viral vector for gene therapy. In these helper dependent virus or packaging cell line assisted produced vectors the … See more

SV40 consists of an unenveloped icosahedral virion with a closed circular double-stranded DNA genome of 5.2 kb. The virion adheres to cell surface receptors of MHC class I by the virion glycoprotein VP1. Penetratio… See more

SV40 is capable of multiplicity reactivation (MR). MR is the process by which two or more virus genomes containing otherwise lethal damage interact within an infected cell to form a viable virus genome. Yamamato … See more

The early promoter for SV40 contains three elements. The TATA box is located approximately 20 base-pairs upstream from the transcriptional start site. The 21 base-pair repeats contain six GC boxes and are the site tha… See more

SV40 is dormant and is asymptomatic in rhesus monkeys. The virus has been found in many macaque populations in the wild, where it rarely causes disease. However, in monkeys that are immunodeficient—due to, for exampl… See more