SHP2 is a multifunctional therapeutic target in drug resistant ...
Oct 8, 2020 · Tyrosine kinase inhibitors targeting human epidermal growth factor receptor 2 (HER2), such as lapatinib and neratinib, can provide therapeutic benefit to HER2 + patients. However, inherent and ...
SHP2是生长因子和免疫检查点信号通路的重要调节因子 - 知乎
SHP2 是近年新兴的一个明星抗肿瘤药物靶点，是由 PTPN11 基因编码的细胞质非受体蛋白酪氨酸磷酸酶（protein tyrosinephosphatase，PTP），包含 2 个 SH2 结构域和 1 个 PTP 催化结构域，可以催化磷酸化的底物（如受体、激酶等）去磷酸化，从而调控下游信号。. SHP2 是 PTP ...
A comprehensive review of SHP2 and its role in cancer
SHP2 modulates diverse cell signaling events that control metabolism, cell growth, differentiation, cell migration, transcription and oncogenic transformation. It interacts with diverse molecules in the cell, and regulates key signaling events including RAS/ERK, PI3K/AKT, JAK/STAT and PD-1 pathways downstream of several receptor tyrosine ...
The SHP-2 tyrosine phosphatase: Signaling mechanisms and biological ...
Dec 1, 2000 · As a protein tyrosine phosphatase, SHP-2 is believed to function by dephosphorylating its associated signaling molecules, thus diminishing the local signaling flow. However, the ultimate effect...
SHP2生物学功能及其在癌症中的作用 - 脉脉
Dec 2, 2022 · shp2的结构与生物学功能. 1 shp2的结构特征. shp2作为一种非受体蛋白酪氨酸磷酸酶，在细胞信号转导的下游发挥重要作用。 shp2受生长因子、细胞因子和整合素受体的调控，参与细胞存活、增殖和迁移等细胞过程。
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current
Oct 22, 2020 · SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally, SHP2 serves as an important hub to connect several intracellular oncogenic signaling pathways, such as Jak/STAT, PI3K/AKT, RAS/Ra ….
A comprehensive review of SHP2 and its role in cancer
Sep 6, 2022 · In view of this, we comprehensively and thoroughly reviewed literatures about SHP2 regulatory mechanisms, substrates and binding partners, biological functions, roles in human cancers, and different classes of small molecule inhibitors target this …
SHP2 blockade enhances anti-tumor immunity via tumor cell
Jan 14, 2021 · SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2.
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current ...
May 27, 2020 · SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally, SHP2 serves as an important hub to connect several intracellular oncogenic signaling pathways, such as Jak/STAT, PI3K/AKT, RAS/Raf/MAPK, and PD-1/PD-L1 pathways.
Double-edged roles of protein tyrosine phosphatase SHP2 in …
Feb 1, 2022 · Phosphorylation is a reversible post-translational modification regulated by phosphorylase and dephosphorylase to mediate important cellular events. Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) encoded by PTPN11 is the first identified oncogenic protein in protein tyrosine phosphatases family.
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