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  1. Wikipedia
    https://en.wikipedia.org/wiki/SV40

    SV40 - Wikipedia

    • SV40 is a DNA virus that can cause tumors in animals, but usually persists as a latent infection. It was contaminated in some polio vaccines in the past, but no increased cancer risk was found. Learn about its virology, gene therapy, and multiplicity reactivation. See more

    Overview

    SV40 is an abbreviation for simian vacuolating virus 40 or simian virus 40, a polyomavirus that is found in both monkeys
    Following … See more

    Human disease

    The hypothesis that SV40 might cause cancer in humans was a particularly controversial area of research, fuelled by the historical contamination of some batches of polio vaccine with SV40 in the 1950s and … See more

    Gene therapy

    Due to its high tissue tropism, biotechnology companies seek to utilize modified SV40 based vectors as a viral vector for gene therapy. In these helper dependent virus or packaging cell line assisted produced vectors the … See more

    Virology

    SV40 consists of an unenveloped icosahedral virion with a closed circular double-stranded DNA genome of 5.2 kb. The virion adheres to cell surface receptors of MHC class I by the virion glycoprotein VP1. Penetratio… See more

    Multiplicity reactivation

    SV40 is capable of multiplicity reactivation (MR). MR is the process by which two or more virus genomes containing otherwise lethal damage interact within an infected cell to form a viable virus genome. Yamamato … See more

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    Overview
    Human disease
    Gene therapy
    Virology
    Multiplicity reactivation
     

  1. Images of SV40 structure

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    Image result for SV40 structure. Size: 165 x 106. Source: www.lsbio.com
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    Image result for SV40 structure. Size: 153 x 100. Source: www.mdpi.com
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    Image result for SV40 structure. Size: 68 x 100. Source: genesdev.cshlp.org
    Image result for SV40 structure. Size: 112 x 100. Source: elifesciences.org
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  2. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC2718763

    SV40 DNA replication: From the A gene to a nanomachine

  3. RCSB PDB
    https://www.rcsb.org/structure/1SVA

    1SVA: SIMIAN VIRUS 40 - RCSB PDB

    The structure of simian virus 40 (SV40), previously determined at 3.8 degree resolution, shows how its pentameric VP1 assembly units are tied together by …

    • Author: Thilo Stehle, Steven J Gamblin, Youwei Yan, Stephen C Harrison
    • Publish Year: 1996
  4. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832212

    SV40 Hijacks Cellular Transport, Membrane Penetration, and …

  5. Frontiers
    https://www.frontiersin.org/journals/immunology...

    How Simian Virus 40 Hijacks the Intracellular Protein Trafficking ...

  7. Science | AAAS
    https://www.science.org/doi/10.1126/sciadv.…

    Revealing in real-time a multistep assembly …

    Apr 15, 2020 · SV40 is a nonenveloped DNA virus belonging to the Polyomaviridae family with a 5.2–kilo–base pair (kbp) circular double-stranded DNA (dsDNA) genome. The native capsid is ~45 nm in diameter (T = 7 …

  8. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985306

    How Simian Virus 40 Hijacks the Intracellular Protein Trafficking ...

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC85533

    Functionally Significant Secondary Structure of the Simian Virus 40 ...

  10. Nature
    https://www.nature.com/articles/nature01691

    Structure of the replicative helicase of the oncoprotein SV40 large ...

  11. Nature
    https://www.nature.com/articles/nsmb1254

    Structural and biochemical insights into the regulation …

    May 27, 2007 · The small t antigen (ST) of DNA tumor virus SV40 facilitates cellular transformation by disrupting the functions of protein phosphatase 2A (PP2A) through a poorly defined mechanism.

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