STAT4 - Wikipedia
Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family, composed of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6. [5] STAT proteins are key activators of gene transcription which bind to DNA in response to cytokine gradient. [6]
STAT4: an immunoregulator contributing to diverse human diseases
Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to the membrane, and then dimerized STAT4 translocates to the nucleus to regulate gene expression.
STAT4 Gene - GeneCards | STAT4 Protein | STAT4 Antibody
Oct 2, 2024 · STAT4 (Signal Transducer And Activator Of Transcription 4) is a Protein Coding gene. Diseases associated with STAT4 include Disabling Pansclerotic Morphea Of Childhood and Systemic Lupus Erythematosus 11. Among its related pathways are Interleukin-12 family signaling and IL27-mediated signaling events.
STAT4 gene - MedlinePlus
The STAT4 gene provides instructions for a protein that acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and helps control the activity of certain genes. Learn about this gene and related health conditions.
The JAK/STAT signaling pathway: from bench to clinic
Nov 26, 2021 · STAT4, STAT5, and STAT6 can be used as targets for ubiquitin-dependent destruction, while STAT1, STAT2, and STAT3 are more stable, indicating that the transcriptional active region also regulates...
STAT4 is expressed in neutrophils and promotes antimicrobial …
Jul 7, 2021 · STAT4 is expressed in neutrophils, is activated by IL-12, and regulates gene expression profile of neutrophils. BM neutrophils were treated with IL-12 (40 ng/mL) for indicated time points. (A) The expression of phosphorylated STAT4/STAT4 (p-STAT4/STAT4) or (B) p-JAK/JAK was examined by Western blot.
STAT4: a critical regulator of inflammation in vivo - PubMed
Signal transducer and activator of transcription 4 (STAT4) is a central mediator in generating inflammation during protective immune responses and immune-mediated diseases. In the 8 yr since their first description, STAT4-deficient mice have defined the role of STAT4 in a variety of in vivo model sy ….
STAT4 signal transducer and activator of transcription 4 [ (human)]
STAT4 plays a crucial role in the function of innate and adaptive immune cells; dysregulated expression and aberrant activation of STAT4 is observed in many human autoimmune conditions. genetic variations in STAT4 predispose to lupus nephritis and a …
STAT4: Genetics, Mechanisms, and Implications for Autoimmunity …
STAT4 is a transcription factor that transduces interleukin-12, interleukin-23, and type I interferon cytokine signals in T cells and monocytes, leading to T-helper type 1 and T-helper type 17 differentiation, monocyte activation, and production of interferon-γ.
The pro-inflammatory signalling regulator Stat4 promotes
Mar 3, 2017 · Nature Communications - Stat4 is a transcription factor known to regulate pro-inflammatory signalling. Here, Menget al. show that Stat4 is not only regulating inflammation but it is also...