SLX4 Gene - GeneCards | SLX4 Protein | SLX4 Antibody
WEBAug 6, 2024 — SLX4 (SLX4 Structure-Specific Endonuclease Subunit) is a Protein Coding gene. Diseases associated with SLX4 include Fanconi Anemia, Complementation Group P and Fanconi Anemia, Complementation Group A.
SLX4 interacts with RTEL1 to prevent transcription-mediated DNA ...
WEBMay 11, 2020 — The SLX4 tumor suppressor is a scaffold that plays a pivotal role in several aspects of genome protection, including homologous recombination, interstrand DNA crosslink repair and the...
The role of SLX4 and its associated nucleases in DNA interstrand ...
WEBMar 3, 2019 — SLX4/FANCP is a large scaffold protein that plays a central role in ICL unhooking. It contains multiple domains that interact with many proteins including three different endonucleases and also acts in several other DNA repair pathways.
SLX4 Prevents GEN1-Dependent DSBs During DNA Replication
WEBMar 14, 2017 — SLX4 is a versatile protein serving as docking for multiple structure-specific endonucleases during DNA repair, however, little is known about its function at demised replication forks.
Coordinated roles of SLX4 and MutSβ in DNA repair and the …
WEBApr 1, 2021 — SLX4 provides a molecular scaffold for the assembly of multiple protein complexes required for the maintenance of genome stability. It is involved in the repair of DNA crosslinks, the resolution of recombination intermediates, the response to replication stress and the maintenance of telomere length.
SLX4: multitasking to maintain genome stability - PubMed
WEBThis review aims at providing an up-to-date and comprehensive view on the key functions that SLX4 fulfills to maintain genome stability as well as to highlight and discuss areas of uncertainty and emerging concepts.
SLX4: Not SIMply a Nuclease Scaffold? - Cell Press
WEBJan 8, 2015 — SLX4, a large, multidomain scaffolding protein, has emerged as a key component of several such pathways (Kottemann and Smogorzewska, 2013). Through a remarkable ability to bind several DNA repair nucleases, including MUS81-EME1, SLX1, and XPF-ERCC1, as well as other genome stability maintenance factors, SLX4 has …
Phosphorylation of the DNA repair scaffold SLX4 drives folding of …
WEBOct 25, 2022 — The DNA repair scaffold SLX4 has multifaceted roles in genome stability, many of which depend on structure-selective endonucleases. SLX4 coordinates the cell cycle-regulated assembly of SLX1, MUS81-EME1, and XPF-ERCC1 into a tri-nuclease complex called SMX.
SLX4, a coordinator of structure-specific endonucleases, is mutated …
WEBJan 16, 2011 — SLX4, which coordinates three separate endonucleases, was recently recognized as an important regulator of DNA repair. Here we report the first human individuals found to have biallelic mutations...
Coordinated roles of SLX4 and MutSβ in DNA repair and the ... - PubMed
WEBSLX4 provides a molecular scaffold for the assembly of multiple protein complexes required for the maintenance of genome stability. It is involved in the repair of DNA crosslinks, the resolution of recombination intermediates, the response to replication stress and the maintenance of telomere length ….
- Some results have been removed