INPP5D - Wikipedia
WEBSrc homology 2 (SH2) domain containing inositol polyphosphate 5-phosphatase 1 (SHIP1) is an enzyme with phosphatase activity. SHIP1 is structured by multiple domain and is encoded by the INPP5D gene in humans.
INPP5D Gene - GeneCards | SHIP1 Protein | SHIP1 Antibody
WEBAug 6, 2024 · Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis.
Targeting SHIP1 and SHIP2 in Cancer - PMC - National Center for ...
WEBFeb 20, 2021 · The SH2-containing 5′ inositol phosphatases, SHIP1 and SHIP2, are regulators of the PI3K/AKT pathway that have crucial roles in cancer progression. This review aims to summarize the role of SHIP1 and SHIP2 in cancer signaling and the immune response to cancer, the discovery and use of SHIP inhibitors and agonists as possible …
Regulation of immune cell signaling by SHIP1: A phosphatase, …
WEBThe phosphoinositide phosphatase SHIP is a critical regulator of immune cell activation. Despite considerable study, the mechanisms controlling SHIP activity to ensure balanced cell activation remain incompletely understood. SHIP dampens BCR signaling in part through its association with the inhibitory coreceptor Fc gamma receptor IIB, and ...
SHIP1 and its role for innate immune regulation—Novel targets …
WEBGeneral overview of SHIP1 regulation of innate immune mechanisms. SHIP1 restrains the production of inflammatory mediators by innate immune cells (type 2 innate lymphoid cells [ILCs], basophils, mast cells, macrophages, conventional dendritic cells [cDCs], plasmacytoid dendritic cells [pDCs], microglia).
Role of SHIP1 in cancer and mucosal inflammation - PMC
WEBThe SH-2 containing inositol 5’ polyphosphatase 1 (SHIP1) is a multifunctional protein expressed predominantly, by hematopoietic cells. SHIP1 removes the 5’ phosphate from the product of PI3K, PI (3,4,5)P 3, to generate PI (3,4)P 2. Both PIP species influence the activity level of Akt, and ultimately regulate cell survival and differentiation.
INPP5D regulates inflammasome activation in human microglia
WEBNov 29, 2023 · Abstract. Microglia and neuroinflammation play an important role in the development and progression of Alzheimer’s disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1)...
SHIP1 and its role for innate immune regulation-Novel targets for ...
WEBIn immune cells, this PI3K/AKT pathway is critically regulated by the phosphoinositide phosphatase SHIP1, which has been reported to modulate the function of most immune subsets.
SHIP1, an SH2 Domain Containing Polyinositol-5-phosphatase, Regulates ...
WEBSHIP1 is an SH2 domain containing inositol-5-phosphatase that appears to be a negative regulator of hematopoiesis. The tyrosine kinase oncogene BCR/ABL drastically reduces expression of SHIP1. The major effect of re-expressing SHIP1 in BCR/ABL-transformed cells is reduction of hypermotility.
SHIP1, but not an AML-derived SHIP1 mutant, suppresses myeloid leukemia ...
WEBNov 16, 2017 · The SH2-containing inositol 5-phosphatase 1 (SHIP1) is a negative regulator of PI3K/AKT signaling in hematopoietic cells. SHIP1 knockout mice develop a myeloproliferative syndrome and...