The raphe nuclei (Greek: ῥαφή, "seam") [1] are a moderate-size cluster of nuclei found in the brain stem. They have 5-HT1 receptors which are coupled with Gi/Go-protein-inhibiting adenyl cyclase. They function as autoreceptors in the brain and decrease the release of serotonin.

May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.

What are the raphe nuclei and what do they do? The raphe nuclei are the primary location in the brain for the production of the neurotransmitter serotonin, and the serotonin synthesized in the raphe nuclei is then sent throughout the entire central nervous system. Although the raphe nuclei represent the largest collection of serotonin neurons ...

The dorsal raphe nucleus (DRN) is a major source of neuromodulators in the central nervous system, and is the largest of the serotonergic nuclei, containing approximately a third of all serotonergic neurons (5-HT neurons) in the brain (Hornung, 2010).

The raphe nuclei are at the center of serotoninergic transmission in the brain. The more dorsal nuclei project to the brain (cortex, amygdala, caudate, putamen others?). The more ventral ones project to the spine (and involved in descending modulation of pain).

May 1, 2023 · The raphe nuclei are positioned midline in the brainstem throughout the midbrain, pons, and medulla. These nuclei contain primarily serotonergic neurons, which release serotonin (5-hydroxytryptamine) with autocrine and paracrine effects, as well as synaptic connections.

The raphe nuclei are a collection of functionally and anatomically diverse cell groups that span the brainstem and contain the majority of the serotonin-producing neurons in the central nervous system. The organization and physiology of the raphe nuclei are comprehensively reviewed elsewhere (see Refs. Jacobs and Azmitia, 1992; Lowry, 2002). In ...

The raphe nuclei are a moderate-size cluster of nuclei found in the brain stem. Their main function is to release serotonin to the rest of the brain. Selective serotonin reuptake inhibitor antidepressants are believed to act in these nuclei, as well as at their targets. The raphe nuclei have a vast impact upon the central nervous system.

Mar 2, 2021 · The raphe nuclei, which are neuronal aggregates divided into paired nuclei along the brainstem, perform vital functions related to stimulus responsiveness, sleep, and wakefulness. However, the most important and best known of all is the …

The median raphe and dorsal raphe nuclei provide parallel and overlapping projections to many forebrain structures with axon fibers exhibiting distinct structural and functional characteristics.