Jun 1, 2006 · The stacking of cells (rouleaux formation) facilitates the rate of red cell sedimentation, a phenomenon that may be seen on a peripheral smear. The appearance of rouleaux may be artificially caused by a poor preparation of the smear or by viewing the slide in a thickened area.

Rouleaux (singular is rouleau) are stacks or aggregations of red blood cells (RBCs) that form because of the unique discoid shape of the cells in vertebrates. The flat surface of the discoid RBCs gives them a large surface area to make contact with …

In pathological states, the increase of plasma proteins (e.g. fibrinogen, globulins) will coat the red blood cells and cause them to become “sticky” and result in rouleaux formation. 1,4

Oct 31, 2023 · Rouleaux formation is the loose aggregation of red cells that occurs in most human blood when left for a time in stasis. The aggregates have a characteristic morphology with the cells adherent face-to-face to produce columns of cells similar to piles of coins.

Nov 5, 2016 · Red blood cell (RBC) rouleaux formation is a reversible phenomenon that occurs during low blood flow and small shearing forces in circulation. Certain pathological conditions can alter the molecular constituents of blood and properties of the RBCs leading to enhanced rouleaux formation, which results in impaired perfusion and tissue oxygenation ...

Red Cell Clumping (Agglutination) Agglutination describes the clumping together of red blood cells (RBCs) on a peripheral blood smear. Unlike rouleaux formation, where RBCs stack in a specific pattern, agglutination appears as irregular, dense clusters of clumped cells.

Erythrocyte aggregation is the reversible clumping of red blood cells (RBCs) under low shear forces or at stasis. Erythrocytes aggregate in a special way, forming rouleaux. Rouleaux are stacks of erythrocytes which form because of the unique …

Oct 27, 2015 · Rouleaux formation in a patient with plasma cell myeloma. Rouleaux formation refers to the stacking of 4 or more red blood cells. Red cell membranes have a negative charge (zeta potential) that causes red cells to repel each other.

Rouleaux formation is the arrangement of red blood cells in fluid blood (or in diluted suspensions) with their biconcave surfaces in apposition, thereby forming groups that resemble stacks of coins. SYN: pseudoagglutination. anaemia of acute or chronic disease, alone or combined with iron deficiency anaemia - not Fe deficiency alone.

The RBC's here have stacked together in long chains. This is known as "rouleaux formation" and it happens with increased serum proteins, particularly fibrinogen and globulins. Such long chains of RBC's sediment more readily.