Protein synthesis inhibitor - Wikipedia
WEBA protein synthesis inhibitor is a compound that stops or slows the growth or proliferation of cells by disrupting the processes that lead directly to the generation of new proteins. [1] A ribosome is a biological machine that utilizes protein dynamics on nanoscales to translate RNA into proteins.
Recent advances in the development of protein–protein ... - Nature
WEBSep 23, 2020 · Protein–protein interactions (PPIs) have pivotal roles in life processes. The studies showed that aberrant PPIs are associated with various diseases, including cancer, infectious diseases, and...
Recent advances in targeting the “undruggable” proteins: from …
WEBSep 6, 2023 · Covalent inhibitors bind to amino acid residues of target proteins through covalent bonds formed by mildly reactive functional groups to confer additional affinity.
Protein kinase inhibitor - Wikipedia
WEBA protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. Protein kinases are enzymes that phosphorylate (add a phosphate, or PO 4, group) to a protein and can modulate its function. The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the protein.
A Quick Guide to Small-Molecule Inhibitors of Eukaryotic Protein ...
WEBNov 26, 2020 · In this article, we review well-studied and less known inhibitors of eukaryotic protein synthesis (with the exception of mitochondrial and plastid translation) classified by their targets and briefly describe the action mechanisms of these compounds.
Inhibitors of Protein-Protein Interactions (PPIs): An Analysis of ...
WEBProtein-protein interactions (PPI) were once considered “undruggable”, but clinical successes, driven by advanced methods in drug discovery, have challenged that notion. Here, we review the last three years of literature on PPI inhibitors to understand what is working and why.
Protease inhibitor (biology) - Wikipedia
WEBProteinase propeptide inhibitors (sometimes referred to as activation peptides) are responsible for the modulation of folding and activity of the peptidase pro-enzyme or zymogen. The pro-segment docks into the enzyme, shielding the substrate binding site, thereby promoting inhibition of the enzyme.
A comprehensive review of protein kinase inhibitors for cancer …
WEBDysregulation of protein kinases is implicated in various processes of carcinogenesis. The advent of protein kinase inhibitors in cancer therapy has led to a paradigm shift in how we treat cancer. There are several protein kinase inhibitors that have been approved by FDA in the last few decades.
Protein Inhibitor - an overview | ScienceDirect Topics
WEBProteinase inhibitors are a special group of plant proteins brought together due to a common ability to form stoichiometric complexes with proteinases, which leads to competitive inhibition of catalytic activity.
Exploring the chemical space of protein–protein interaction inhibitors …
WEBJun 28, 2021 · These results demonstrate that active compounds with regions of interest in the chemical space may be expected to provide insights into potential PPI inhibitors for particular protein targets.