Proteasome - Wikipedia
The overall system of ubiquitination and proteasomal degradation is known as the ubiquitin–proteasome system. [3] The proteasomal degradation pathway is essential for many cellular processes, including the cell cycle, the regulation of gene expression, and responses to oxidative stress.
The proteasome: structure, function, and role in the cell
The proteasome is a multisubunit enzyme complex that plays a central role in the regulation of proteins that control cell-cycle progression and apoptosis, and has therefore become an important target for anticancer therapy.
The proteasome: overview of structure and functions - PubMed
The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated proteolysis in eukaryotic cells.
The Proteasome and its Role in the Nervous System - PMC
Proteasomes are multisubunit complexes that catalyze the majority of protein degradation in mammalian cells to maintain protein homeostasis and influence the regulation of most cellular processes. The proteasome, a multicatalytic protease complex, ...
Proteasome - an overview | ScienceDirect Topics
The proteasome is a major proteolytic complex responsible for the degradation and recycling of proteins and therefore plays an important role in intracellular protein quality control
The proteasome: A key modulator of nervous system function, …
The proteasome is a large multi-subunit protease responsible for the degradation and removal of oxidized, misfolded, and polyubiquitinated proteins. The proteasome plays critical roles in nervous system processes. This includes maintenance of ...
Role of Proteasomes in Inflammation - PMC - National Center for ...
Apr 20, 2021 · The ubiquitin–proteasome system (UPS) is involved in multiple cellular functions including the regulation of protein homeostasis, major histocompatibility (MHC) class I antigen processing, cell cycle proliferation and signaling.
Proteasome - an overview | ScienceDirect Topics
The proteasome is a component of the ubiquitin-proteasome system, the major ATP-dependent proteolytic machinery in cells. It is responsible for the bulk of protein degradation and it is therefore crucial to the maintenance of cell homeostasis, as well as for cell differentiation, cell-cycle progression, and apoptosis.
Proteasome Structure and Assembly - PMC - PubMed Central (PMC)
The eukaryotic 26S proteasome is a large multi-subunit complex that degrades the majority of proteins in the cell under normal conditions. The 26S proteasome can be divided into two subcomplexes: the 19S regulatory particle (RP) and the 20S core particle (CP).
The Proteasome and Its Network: Engineering for Adaptability
The proteasome, the most complex protease known, degrades proteins that have been conjugated to ubiquitin.
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