Phospholipase D1 - Wikipedia
WEBPhospholipase D 1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5] [6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [7]
PLD1 is a key player in cancer stemness and chemoresistance ...
WEBJul 1, 2024 · As PLD1 is a novel target of vorinostat resistance, combination therapy with PLD1 inhibitors and vorinostat may represent a potential therapeutic strategy against GBM tumorigenesis.
PLD1 Gene - GeneCards | PLD1 Protein | PLD1 Antibody
WEBAug 6, 2024 · PLD1 (Phospholipase D1) is a Protein Coding gene. Diseases associated with PLD1 include Cardiac Valvular Dysplasia 1 and Heart Disease. Among its related pathways are Glycerophospholipid biosynthesis and Signaling by Rho GTPases.
Crystal structure of human PLD1 provides insight into ...
WEBMar 16, 2020 · The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as...
Targeting phospholipase D in cancer, infection and ... - Nature
WEBFeb 17, 2017 · The phospholipase D (PLD) isoenzymes PLD1 and PLD2 are one of the major sources of signal-activated phosphatidic acid (PtdOH) generation downstream of a variety of cell-surface receptors,...
Phospholipase D - Wikipedia
WEBPhospholipase D (EC 3.1.4.4, lipophosphodiesterase II, lecithinase D, choline phosphatase, PLD; systematic name phosphatidylcholine phosphatidohydrolase) is an enzyme of the phospholipase superfamily that catalyses the following reaction. a phosphatidylcholine + H 2 O = choline + a phosphatidate.
Physiological and pathophysiological roles for phospholipase D
WEBThe mammalian phospholipase D (PLD) superfamily is best known for the catalytic action of its classical family members which hydrolyze phosphatidylcholine, the most abundant membrane phospholipid, to generate choline and the second messenger signaling lipid, phosphatidic acid (PA) (1).