Pimagedine - Wikipedia
WEBPimagedine, also known as aminoguanidine, is an investigational drug for the treatment of diabetic nephropathy that is no longer under development as a drug. [1] Pimagedine functions as an inhibitor of diamine oxidase and nitric oxide synthase.
Pimagedine: Uses, Interactions, Mechanism of Action - DrugBank …
WEBNov 18, 2007 — Pimagedine has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease. It is an advanced glycation end product inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies.
Use of aminoguanidine (Pimagedine) to prevent the formation of …
WEBNov 1, 2003 — Aminoguanidine (AG) is a prototype therapeutic agent for the prevention of formation of advanced glycation endproducts. It reacts rapidly with alpha,beta-dicarbonyl compounds such as methylglyoxal, glyoxal, and 3-deoxyglucosone to prevent the formation of advanced glycation endproducts (AGEs).
Pimagedine hydrochloride - DrugBank Online
WEBPimagedine. Pimagedine has been developed by Synvista Therapeutics, Inc for the treatment of diabetic kidney disease. It is an advanced glycation end product inhibitor which manages diabetic nephropathy, either alone or in combination with other therapies.
Pimagedine: a novel therapy for diabetic nephropathy - PubMed
WEBPimagedine (aminoguanidine HCl) has been shown to be an effective agent in reducing the severity of the structural and functional alterations associated with experimental diabetic nephropathy. Preliminary studies suggest a beneficial effect of pimagedine in treating patients with diabetic nephropathy.
Use of aminoguanidine (Pimagedine) to prevent the formation of …
WEBNov 1, 2003 — Aminoguanidine (Pimagedine, AG) 1 is a prototype α,β-dicarbonyl scavenging agent that prevents the formation of advanced glycation endproducts (AGEs) from α,β-dicarbonyl precursors (Fig. 1). The first report of intervention to prevent AGE formation by AG was the prevention of diabetes-induced arterial wall protein crosslinking [1] .
PIMAGEDINE HYDROCHLORIDE - National Center for Advancing …
WEBPimagedine is a nucleophilic hydrazine. It was shown to inhibit diamine oxidase (histaminase), which catalyzes the oxidative deamination of diamines histamine and putrescine. Pimagedine was also reported to inhibit nitric oxide synthase (NOS) based on its structural similarity to the NOS substrate L-arginine.
Early closure of European Pimagedine trial - The Lancet
WEBA randomised controlled clinical trial of the effects of Pimagedine (aminoguanidine) on the progression of early renal disease (microalbuminuria) in insulin-dependent diabetic patient volunteers was discontinued for financial reasons by …
Advanced Glycation End Products in Health and Disease - PMC
WEBSep 15, 2022 — Aminoguanidine (pimagedine), as an AGE inhibitor, has received more attention than any other AGE inhibitors. Polyphenolic compounds have multiple mechanisms of action in attenuating the levels of AGEs and, as naturally occurring compounds, have no adverse effects, unlike synthetic AGE inhibitors, including aminoguanidine.
Randomized trial of an inhibitor of formation of advanced …
WEBBackground/aims: Pimagedine inhibits the formation of advanced glycation end products and slows the progression of diabetic complications in experimental models. This study was undertaken to determine if pimagedine ameliorates nephropathy in type 1 (insulin-dependent) diabetes mellitus.