PIM1 - Wikipedia
WEBPim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by the Moloney murine leukemia virus. [8] .
Designing Intrinsically Microporous Polymer (PIM-1 ...
WEBMay 8, 2020 · In this study, we present the fabrication of fibers with tunable morphology and porosity from an intrinsically microporous polymer, PIM-1, using a simple one-step electrospinning technique.
PIM1 Gene - Pim-1 Proto-Oncogene, Serine/Threonine Kinase
WEBAug 6, 2024 · PIM1 (Pim-1 Proto-Oncogene, Serine/Threonine Kinase) is a Protein Coding gene. Diseases associated with PIM1 include Myeloma, Multiple and Thrombocythemia 1. Among its related pathways are FLT3 signaling in …
Pim-1 kinase as cancer drug target: An update - PMC
WEBDec 24, 2015 · Recent studies show that mitochondrial Pim-1 maintains mitochondrial integrity. Pim-1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim-1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found.
Serine/Threonine Protein Kinase Pim 1 drugs in development, 2024
WEBProto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme encoded by the PIM1 gene. It promotes cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression CDKN1B at both transcriptional and post-translational levels.
Clinical Significance of Pim-1 in Human Cancers: A Meta ...
WEBJul 16, 2022 · High Pim-1 can not only predict poor OS and DFS of cancer, but also help to infer the malignant clinical characteristics of tumor metastasis. Pim-1 may be a potential and promising biomarker for early diagnosis, prognostic analysis and targeted therapy of tumors.
A systematic review on active sites and functions of PIM-1 ...
WEBMar 17, 2021 · Understanding the role of PIM-1 active sites can facilitate the exploration the mechanism of its function, thereby activating or inhibiting PIM-1 kinase by modifying these active sites, which would offer more potential strategy to study the signal pathway, physiology and pathology involved in PIM-1.