Clinical significance of high expression of proliferating cell nuclear ...
PCNA expression in NSCLC and adjacent tissues were assessed by immunohistochemistry (IHC), western blotting, and reverse transcription polymerase chain reaction. Single factor analysis was used to study the relationship between the expression of PCNA and clinicopathological features of NSCLC.
Immunohistochemical detection of proliferating cell nuclear …
Jun 6, 1997 · The PCNA labeling index (LI) was assessed by counting the positively-stained nuclei per 500 cells. RESULTS: PCNA LI ranged from 1.8% to 91.4% (mean = 33.9%) in cancerous tissues, and was significantly related to the tumor size, histological grade, mitotic count and the metastases found in HCC samples.
Prognostic Biomarkers of Cell Proliferation in Colorectal Cancer …
Sep 15, 2023 · Among the immunohistochemical (IHC) proliferative markers, the prognostic value regarding the patients’ overall survival (OS) or disease-free survival (DFS) has been confirmed for thymidylate synthase (TS), cyclin B1, cyclin D1, proliferating cell nuclear antigen (PCNA), and Ki …
Ki67, PCNA, and MCM proteins: Markers of proliferation in the …
Jun 1, 2016 · A very promising methodology is tissue microarray (TMA) and IHC/digital imaging of primary invasive breast cancers to analyse the gene expression of the proliferation markers Ki67, MCM2, and geminin. The results from digital imaging were comparable to those from light microscopy-based scoring.
Comparison of the value of PCNA and Ki-67 as markers of cell ...
Many investigations of tumor-cell proliferative activity have used PCNA and Ki-67 to evaluate cell proliferation in oral tumors (16 - 18). The aim of this study was to determine which of the two markers is more useful to evaluate cell proliferation in the study of ameloblastic tumors.
Prognostic value and clinicopathological significance of …
Jan 10, 2017 · First, PCNA expression in gastric cancer tissues was detected by IHC in all included studies, but the accuracy of this method is dependent on the types of antibodies and their dilutions. As not all studies used the same primary antibody or …
Assessment of proliferating cell nuclear antigen (PCNA) …
Oct 31, 2019 · Proliferating Cell Nuclear Antigen (PCNA) is a nuclear protein and marker of cell proliferation. PCNA is strongly related to prognosis and survival in most types of solid malignancies, such as colorectal cancer and breast cancer [12, 13, 14].
Proliferating Cell Nuclear Antigen Has an Association with …
Nov 12, 2015 · Patients with positive PCNA were investigated mainly by IHC methods, instead of RT-PCR and Western blot. Based on the description of IHC methods, PCNA expression can be defined as positive if the nucleus or cytoplasm was stained.
The clinical utility of the proliferating cell nuclear antigen ...
Proliferating cell nuclear antigen (PCNA) has been suggested as a potential diagnostic biomarker for early hepatocellular carcinoma (HCC). However, its prognostic significance in HCC remains unclear. In the present study, we investigated the expression and significance of PCNA in HCC and then analyz ….
Targeting Proliferating Cell Nuclear Antigen (PCNA) as an Effective ...
Here, we describe the status of the art in the development of agents targeting PCNA and discuss their application in different types of tumor cell lines and in animal model systems.