PTPN11 - Wikipedia
PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.
PTPN11 gene - MedlinePlus
The PTPN11 gene provides instructions for making a protein called SHP-2. Learn about this gene and related health conditions.
PTPN11 Gene - GeneCards | PTN11 Protein | PTN11 Antibody
Oct 2, 2024 · PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) is a Protein Coding gene. Diseases associated with PTPN11 include Noonan Syndrome 1 and Juvenile Myelomonocytic Leukemia . Among its related pathways are Downstream signaling of activated FGFR2 and Negative regulation of FGFR3 signaling .
PTPN11 protein tyrosine phosphatase non-receptor type 11
PTPN11 plays a role in regulating neurotrophin protective signaling in neuronal cells; PTPN11 dysregulation promotes apoptotic activation. This study provides information on phenotypes observed in Noonan syndrome patients with different …
Molecular, clinical, and prognostic implications of PTPN11 …
Feb 25, 2022 · Prognostic factors associated with chemotherapy outcomes in patients with acute myeloid leukemia (AML) are extensively reported, and one gene whose mutation is recognized as conferring resistance to several newer targeted therapies is protein tyrosine phosphatase non-receptor type 11 (PTPN11).
Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase - Nature
May 28, 2018 · The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine and integrin...
PTPN11 Mutations in the Ras-MAPK Signaling Pathway Affect …
Abstract. We examined whether PTPN11 mutations affect the white matter connectivity of the developing human brain. Germline activating mutations to the PTPN11 gene cause overactivation of the Ras-Mitogen-Activated Protein Kinase pathway. Activating mutations cause Noonan syndrome (NS), a developmental disorder associated with hyperactivity and cognitive …
PTPN11 protein tyrosine phosphatase non-receptor type 11
Nov 3, 2024 · This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
PTPN11 protein tyrosine phosphatase non-receptor type 11 …
Apr 23, 2021 · Title: Clinical Variability in a Family with Noonan Syndrome with a Homozygous PTPN11 Gene Variant in Two Individuals. Mutations in PTPN11 could lead to a congenital myasthenic syndrome phenotype: a Noonan syndrome case series.
About Noonan Syndrome - National Human Genome Research …
Dec 23, 2013 · Four genes - PTPN11, SOS1, RADF1and KRAS - are the only genes that are known to be associated with Noonan syndrome. Approximately 50 percent of individuals with Noonan syndrome have mutations in the PTPN11 gene.