PTK2 Gene - GeneCards | FAK1 Protein | FAK1 Antibody
WEBAug 6, 2024 — PTK2 (Protein Tyrosine Kinase 2) is a Protein Coding gene. Diseases associated with PTK2 include Glioma Susceptibility 1 and Colon Adenocarcinoma. Among its related pathways are Regulation of actin dynamics for phagocytic cup formation and Integrin Pathway.
PTK2B promotes TBK1 and STING oligomerization and enhances …
WEBNov 21, 2023 — Here, we show that protein tyrosine kinase 2 beta (PTK2B) acts as a TBK1-interacting protein and regulates TBK1 oligomerization.
Protein tyrosine kinase 2: a novel therapeutic target to …
WEBDec 2, 2019 — Protein tyrosine kinase 2 (PTK2) expression has been reported in various types of human epithelial cancers including lung cancer; however, the role of PTK2 in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) has not been elucidated.
Targeting FAK in anticancer combination therapies - Nature
WEBMar 17, 2021 — FAK is encoded by the PTK2 gene; PTK2 mutations are rare in cancer, primarily occurring in tumours of the uterus (9.24% of 530 cases), colon (7.25% of 400 cases) and liver (3.92% of 51 cases),...
FAK in cancer: mechanistic findings and clinical applications
WEBAug 7, 2014 — Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. FAK promotes tumour progression and...
FAK in Cancer: From Mechanisms to Therapeutic Strategies
WEBFeb 2, 2022 — FAK is encoded by the protein tyrosine kinase 2 (PTK2) gene located on chromosomal region 8q24.3. The structure of FAK is composed of an amino-terminal band 4.1–ezrin–radixin–moesin (FERM) domain, followed by a kinase domain, and a carboxy-terminal focal adhesion targeting (FAT) domain.
5747 - Gene ResultPTK2 protein tyrosine kinase 2 [ (human)]
WEBThis gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies.
PTK2 - an overview | ScienceDirect Topics
WEBFocal adhesion tyrosine kinase (PTK2) is a cytoplasmic protein tyrosine kinase that overexpressed and activated in many types of advanced-stage solid cancers. PTK2 is reported to play an important role in adhesion, spreading, motility, invasion, metastasis, survival, angiogenesis, epithelial to mesenchymal transition, cancer stem cells, and the ...
Recent progress on FAK inhibitors with dual targeting ... - PubMed
WEBFocal adhesion kinase (FAK, also known as PTK2) is a tyrosine kinase that regulates integrin and growth factor signaling pathways and is involved in the migration, proliferation and survival of cancer cells. FAK is a promising target for cancer treatment.
Quantitative phosphoproteomics uncovers dysregulated kinase …
WEBJun 14, 2021 — This analysis also found several new kinase phosphosites that were correlated with these pathologies, including CDKL5, CDK16 and CDK17, as well as tyrosine kinases SRC, EGFR, DDR1 and PTK2.
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