Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target …
WEBSep 1, 2020 · Phosphoglycerate kinase 1 (PGK1) is the first critical enzyme to produce ATP in the glycolytic pathway. PGK1 is not only a metabolic enzyme but also a protein kinase, which mediates the tumor growth, migration and invasion through phosphorylation some important substrates.
PGK1 Gene - GeneCards | PGK1 Protein | PGK1 Antibody
WEBOct 2, 2024 · PGK1 (Phosphoglycerate Kinase 1) is a Protein Coding gene. Diseases associated with PGK1 include Phosphoglycerate Kinase 1 Deficiency and Hemolytic Anemia. Among its related pathways are glycolysis (BioCyc) and Gluconeogenesis.
Phosphoglycerate kinase 1 acts as a cargo adaptor to promote …
WEBFeb 3, 2024 · Here, we find that phosphoglycerate kinase 1 (PGK1) is recruited to endosomal membrane upon its phosphorylation, where it binds to the dileucine sorting signal in EGFR to promote the...
Hypoxia-induced downregulation of PGK1 crotonylation promotes ...
WEBAug 12, 2024 · Abolishment of PGK1 Kcr promotes glycolysis and suppresses mitochondrial pyruvate metabolism by activating pyruvate dehydrogenase kinase 1 (PDHK1). A low PGK1 K131cr level is correlated with...
Phosphoglycerate kinase is a central leverage point in Parkinson’s ...
WEBAug 21, 2024 · Several recent discoveries point to a critical but unexpected outsized role of the glycolytic enzyme phosphoglycerate kinase 1 (PGK1) in protecting neurons against neurological impairment. PGK1, the first ATP-producing enzyme in glycolysis, catalyzes the sixth step in this 10-step enzymatic cascade.
O-GlcNAcylation of PGK1 coordinates glycolysis and TCA cycle
WEBJan 7, 2020 · We demonstrate here that phosphoglycerate kinase 1 (PGK1), the first ATP-producing enzyme in glycolysis, is reversibly and dynamically modified with O-linked N-acetylglucosamine (O-GlcNAc) at...
The role of an energy-producing enzyme in treating Parkinson’s
WEBAug 22, 2024 · An enzyme called PGK1 has an unexpectedly critical role in the production of chemical energy in brain cells, according to a preclinical study led by researchers at Weill Cornell Medicine.
The basic functions of phosphoglycerate kinase 1 and its roles in ...
WEBApr 5, 2022 · Phosphoglycerate kinase 1 (PGK1) is an essential enzyme that catalyzes adenosine 5'-triphosphate (ATP) production in aerobic glycolysis. In addition to regulating cell metabolism, PGK1 is involved in multiple biological activities, including angiogenesis, mediated autophagy starting, binding of plas ….
The basic functions of phosphoglycerate kinase 1 and its roles in ...
WEBApr 5, 2022 · In this review, we focus on the basic functions of PGK1 and the relationship between PGK1 and different diseases, indicating that PGK1 has a broad application prospect to find a potential biomarker for tumor prognosis and an effective inhibitor.
PGK1 gene - MedlinePlus
WEBThe PGK1 gene provides instructions for making an enzyme called phosphoglycerate kinase. This enzyme is found in cells and tissues throughout the body, where it is involved in a critical energy-producing process known as glycolysis.
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