In this review, we highlight the functions and regulatory mechanisms of PGC-1α within this framework, with a focus on its involvement in the mitochondrial lifecycle and ROS metabolism. As an example, we show the role of PGC-1α in ROS scavenging under inflammatory conditions.

Peroxisome proliferator–activated receptor gamma coactivator-1 alpha (PGC-1a) is a central regulator of metabolism that is poised at the intersection of myriad intracellular signaling pathways.

Peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1alpha is a member of a family of transcription coactivators that plays a central role in the regulation of cellular energy metabolism. It is strongly induced by cold exposure, linking this environmental stimulus to adaptive thermogenesis.

Peroxisome proliferator-activated receptor- γ coactivator (PGC)-1 α is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis and function, including oxidative phosphorylation and reactive oxygen species detoxification.

3 days ago · Cells constantly adjust their energy production to meet changing demands, and PGC-1α plays a central role in this process. This coactivator fine-tunes gene expression to optimize mitochondrial function, making it essential for maintaining cellular energy balance.

Novelty PGC-1α regulates mitochondrial biogenesis but also has effects on mitochondrial functions beyond biogenesis. Mitochondrial quality control mechanisms, including fission, fusion, and mitophagy, are regulated by PGC-1α.

Mar 9, 2020 · Peroxisome proliferator-activated receptor- γ coactivator (PGC)-1 α is a transcriptional coactivator described as a master regulator of mitochondrial biogenesis and function, including oxidative phosphorylation and reactive oxygen species detoxification.

Mar 1, 2024 · Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC),...

Apr 17, 2024 · PGC-1a is the first identified PGC-1 family member, and is tightly modulated by many transduction effectors such as adenosine monophosphate-activated protein kinase (AMPK), silent information...

Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1 α), acted as a transcriptional cofactor, is abundant in the heart, which modulates mitochondrial biogenesis and mitochondrial dynamics and mitophagy to sustain a steady-state of mitochondria.