WEB摘要：聚乙二醇- 聚乳酸嵌段共聚物（peg-pla）及其端基衍生物纳米粒可以增强载药量、降低突释效应、提高药物在血液中的循 环时间、提高生物利用度，并且其粒径更小，能以被动靶向的方式聚集于炎症或靶向部位。
Emerging uses of PLA–PEG copolymer in cancer drug delivery
WEBJan 10, 2022 · Belonging to the class of hydrophilic polymers (PEG), PEG–PLA provide great stabilization to nanoparticles against opsonisation (Elmowafy et al. 2019). Polymer composition largely influences the polymer degradation and the rate of drug release.
Recent advances in PEG-PLA block copolymer nanoparticles
WEBNov 26, 2010 · As a research focus in recent years, polyethylene glycol-polylactic acid (PEG-PLA) block copolymer and its end-group derivative nanoparticles can enhance the drug loading of hydrophobic drugs, reduce the burst effect, avoid being engulfed by phagocytes, increase the circulation time of drugs in blood, and improve bioavailability.
mPEG-PLA and PLA-PEG-PLA nanoparticles as new carriers for
WEBJun 29, 2018 · mPEG-PLA and PLA-PEG-PLA copolymeric nanoparticles with three different PLA to PEG ratios are synthesized and used for encapsulation of recombinant human Growth hormone (rhGH).
吉林大学生命科学学院顾景凯教授团队全面解析PEG-PLA在大鼠体 …
WEB吉林大学生命科学学院顾景凯教授团队全面解析PEG-PLA在大鼠体内的命运 纳米给药系统是对药物进行靶向递释、降低药物毒副作用的新手段。随着聚合物纳米载体在设计、合成方面不断取得进展，聚合物纳米材料在纳米给药系统中得到了广泛的应用，聚合物纳米 ...
Commentary PLA-PEG as an alternative to PEGylated lipids for ...
WEBIn this approach, the conventional DMG-PEG used in approved mRNA vaccines was replaced by PLA-PEG. Huang and colleagues demonstrated that replacing PEGylated lipids with the bioresorbable copolymer PLA-PEG in LNPs enhanced biocompatibility in vitro , suggesting that the selection of surface-active agents may play a crucial role in reducing …
Poly(Ethylene Glycol)–Polylactide Micelles for Cancer Therapy
WEBMar 8, 2018 · Polyethylene glycol (PEG)-polylactide (PLA) is one of the most prominent amphipathic polymers, therefore it is very suitable for constructing micelles. PLA is a form of biodegradable and biocompatible polyester derived from renewable resources and approved by the Food and Drug Administration (FDA) for clinical use.
Polylactic acid (PLA): Properties, synthesis, and biomedical ...
WEBAug 5, 2024 · The most popular hydrophilic polymer for surface modification is recognised to be polyethylene glycol (PEG), which has been used to increase the hydrophilicity of PLA by the generation of the amphiphilic copolymer PEG-PLA. Table 5 gives some examples of polymers commonly used to blend with PLA.
PLA-PEG as an alternative to PEGylated lipids for nanoparticle …
WEBAug 21, 2024 · In this approach, the conventional DMG-PEG used in approved mRNA vaccines was replaced by PLA-PEG. Huang and colleagues demonstrated that replacing PEGylated lipids with the bioresorbable copolymer PLA-PEG in LNPs enhanced biocompatibility in vitro , suggesting that the selection of surface-active agents may play …
Drug-encapsulated blend of PLGA-PEG microspheres: in vitro and …
WEBAug 25, 2020 · In this study, we encapsulated targeted drugs [A bacteria-synthesized anticancer drug (prodigiosin) and paclitaxel] using single solvent evaporation technique with a blend of FDA-approved poly ...
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