However, mutations in p53 are found in most tumor types, and so contribute to the complex network of molecular events leading to tumor formation. The p53 gene like the Rb gene, is a tumor suppressor gene, i.e., its activity stops the formation of tumors.

p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers.

Jan 21, 2025 · What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of tumors.

When p53 co-localizes with DNA-PK and ssDNA, there is a 10-fold enhancement of p53 phosphorylation. All types of tumor cells are shown to exhibit higher levels of p53 phosphorylation when compared to normal non-transformed cells, which offer greater stability to p53 regardless of any p53 mutations.

Since over 50% of human cancers carry loss of function mutations in p53 gene, p53 has been considered to be one of the classical type tumor suppressors. Mutant p53 acts as the dominant-negative inhibitor toward wild-type p53. Indeed, mutant p53 has an oncogenic potential.

In this review, we describe and discuss the multifaceted roles of p53, from its discovery to clinical applications in cancer therapy. p53 tumour suppressor gene is our major barrier against neoplastic transformation.

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

Jan 28, 2021 · The TP53 tumor suppressor is the most frequently mutated gene in human cancer. p53 suppresses tumorigenesis by transcriptionally regulating a network of target genes that play roles in various cellular processes.

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered.

3 days ago · The p53 protein is a key regulator of cellular stress responses, primarily acting as a tumor suppressor by controlling gene expression. Mutations in the TP53 gene are among the most common alterations in human cancers, highlighting its …