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  1. Nature
    https://www.nature.com/articles/s41571-021-00549-2

    The MYC oncogene — the grand orchestrator of cancer growth

    • The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related … See more

    Key points

    •The MYC oncogene is activated in the vast majority of cancers by genetic, epigenetic or … See more

    Nature
    Introduction

    The MYC oncogene (also known as c-MYC) is part of a superfamily of genes with products that are among the most commonly activated in human cancers1,2,… See more

    Nature
    MYC is often activated in human cancers

    Genetic alterations affecting the MYC proto-oncogenes and the MYC-related signalling pathways are among the most common in human cancers1,2,3,4 (Fig. 1). MYC can b… See more

    Nature
    MYC oncogene addiction

    In 2002, Bernard Weinstein proposed that cancers are ‘oncogene addicted’27 following evidence from both experimental mouse models of MYC-driven cancers and clinical stud… See more

    Nature
    Mechanisms of host immune evasion

    MYC activation in cancer cells can impede the host immune response. Conversely, its inactivation seems to restore antitumour immunity in a sequential manner. In an experiment… See more

    Nature
    What are the latest advances in targeting oncogenic Myc?
    In this review, we summarize the latest advances in targeting oncogenic Myc, particularly for cancer therapeutic purposes. The <i>MYC</i> family oncogene is deregulated in >50% of human cancers, and this deregulation is frequently associated with poor prognosis and unfavorable patient survival.
    pubmed.ncbi.nlm.nih.gov
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    Table of Contents
    Key points
    Introduction
    MYC is often activated in human cancers
    MYC oncogene addiction
    Mechanisms of host immune evasion
    What are the latest advances in targeting oncogenic Myc?
     
  1. Studies of Oncogenic MYC
    PubMed
    The MYC oncogene - the grand orchestrator of cancer growth and immune evasion
    The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related pathways by alternate mechanisms occur in the vast majority of cancers. MYC proteins are master regulat...
    Author: Renumathy Dh…
    Published: 2022/1
    Keywords: National In…
    National Center for Biotechnology Information
    Targeting oncogenic Myc as a strategy for cancer treatment
    The MYC oncogene family consists of three members, C-MYC, MYCN, and MYCL, which encode c-Myc, N-Myc, and L-Myc, respectively.1–3 The Myc oncoproteins belong to a family of so-called “super-transcription factors” that potentially regulate the transcription of at least 15% of the entire genome.4 The m...
    Author: Hui Chen, Hud…
    Published: 2018
    Publication: Signal Tra…
    PubMed
    Targeting oncogenic Myc as a strategy for cancer treatment
    The MYC family oncogene is deregulated in >50% of human cancers, and this deregulation is frequently associated with poor prognosis and unfavorable patient survival. Myc has a central role in almost every aspect of the oncogenic process, orchestrating proliferation, apoptosis, differentiation, and m...
    Author: Hui Chen
    Published: 2018/02/23
    Keywords: National In…
    National Center for Biotechnology Information
    Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
    Deregulated metabolism is an essential feature of malignant transformation. To support their relentless cell division, most cancer cells have to evolve specific metabolic adaptations that promote their survival under conditions that kill normal counterparts; this adaptation process has been termed “...
    Author: Yang Dong, R…
    Published: 2020
    Publication: Signal Tra…
    National Center for Biotechnology Information
    Alternative approaches to target Myc for cancer treatment
    The MYC proto-oncogene was originally identified as the cellular homolog to the viral oncogene (v-myc) of the avian myelocytomatosis retrovirus.1 MYC gene and its paralogs (MYCN and MYCL) encode the transcription factors that engage in modulating over 15% of global transcriptome from flies to humans...
    Author: Chen Wang, Ji…
    Published: 2021
    Publication: Signal Tra…
    National Center for Biotechnology Information
    MYC and therapy resistance in cancer: risks and opportunities
    The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways driving cell growth and proliferation. These same processes are deregulated in MYC‐driven tumors, where they become critical for ...
    Author: Giulio Donati, …
    Published: 2022/11
    Publication: Mol Oncol…
    PubMed
    MYC in Regulating Immunity: Metabolism and Beyond
    Myelocytomatosis oncogene (MYC) family members, including cellular MYC (c-Myc), neuroblastoma derived MYC (MYCN), and lung carcinoma derived MYC (MYCL), have all been implicated as key oncogenic drivers in a broad range of human cancers. Beyond cancer, MYC plays an important role in other physiologi...
    Author: J N Rashida G…
    Published: 2017/02/25
    Keywords: MYC; imm…
  2. Nature
    https://www.nature.com/articles/s41388-024-03174-2

    Transcriptional regulation by MYC: an emerging new model

  3. Nature
    https://www.nature.com/articles/s41392-020-00235-2

    Regulation of cancer cell metabolism: oncogenic MYC in the

  4. The Lancet
    https://www.thelancet.com/journals/ebiom/…

    Therapeutic targeting of “undruggable” MYC

    Aug 25, 2021 · Oncogenic levels of MYC promote proliferative signalling, inhibition of growth suppression, escaping immune response, tumour inflammation, angiogenesis, genome instability and changes in cellular …

  5. PubMed
    https://pubmed.ncbi.nlm.nih.gov/34508258

    The MYC oncogene - the grand orchestrator of cancer growth and …

  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5837124

    Targeting oncogenic Myc as a strategy for cancer treatment

  8. PubMed
    https://pubmed.ncbi.nlm.nih.gov/29527331

    Targeting oncogenic Myc as a strategy for cancer treatment

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7351732

    Regulation of cancer cell metabolism: oncogenic MYC in the …

  10. Journal of Hematology & Oncology
    https://jhoonline.biomedcentral.com/articles/10...

    MYC: a multipurpose oncogene with prognostic and therapeutic ...

  11. Cell Press
    https://www.cell.com/cell-reports/fulltext/S…

    Oncogenic MYC Activates a Feedforward Regulatory …

    Dec 26, 2017 · SLC7A5/SLC43A1 depletion inhibits MYC expression, metabolic reprogramming, and tumor cell growth in vitro and in vivo. These findings thus reveal a MYC-SLC7A5/SLC43A1 signaling circuit that underlies EAA …