In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain other molecules.

Nuclear receptors are classically defined as ligand-activated transcription factors that regulate key functions in reproduction, development, and physiology. Humans have 48 nuclear receptors, which when dysregulated are often linked to diseases.

In this article we summarize the birth of the field of nuclear receptors, the discovery of untransformed and transformed isoforms of ligand-binding macromolecules, the discovery of the three-domain structure of the receptors, and the properties of ...

Nuclear receptors are receptors located inside the cell. These receptors are found either in the cytoplasm (Type I) or the nucleus (Type II) of a cell. Examples include: estrogen, glucocorticoids, thyroid hormone T3 or vitamins D and A. Receptor stimulation of any intracellular receptor primarily results in altered gene transcription.

A Nuclear Receptor is a monomeric protein that is involved in modifying gene transcription by binding to specific DNA sequences called hormone response elements, which leads to changes in gene expression within the nucleus. You might find these chapters and articles relevant to …

Ligand-dependent transcription factors are nuclear receptors (NRs) that regulate various critical cellular processes such as reproduction, metabolism, development, etc. NRs are classified into (subgroup 0 to subgroup 6) seven superfamilies based on ligand-binding characteristics.

Jan 1, 2023 · Nuclear receptors (NRs) are thyroid, steroid, vitamin D3, and retinoid receptors found in nematodes, arthropods, and vertebrates.

Nuclear receptors are the class of Intracellular receptors that are always present within the cell and similar to other receptors, they are also protein-base structures. These receptors get activated by lipid-soluble signals like estrogen, thyroid …

Nuclear receptors (NRs) are a family of transcription factors that regulate numerous physiological processes such as metabolism, reproduction, inflammation, as well as the circadian rhythm. NRs sense changes in lipid metabolite levels to drive ...

There are 48 human nuclear receptors, several of which do not have an identified natural ligand and are considered orphan receptors. All nuclear receptors have evolutionarily-conserved sequence similarity, especially within the DNA binding domain and the ligand binding domain.