NLRP12 - Wikipedia
Nucleotide-binding oligomerization domain-like receptor (NLR) pyrin domain (PYD)-containing protein 12 (NLRP12; also known as NACHT, LRR and PYD domains-containing protein 12 or NALP12) is a protein that in humans is encoded by the NLRP12 gene.
NLRP12 in innate immunity and inflammation - PubMed
NLRP12 is a member of the NLR family that contains an N-terminal pyrin domain, a central nucleotide-binding domain, and a C-terminal leucine-rich repeat. It has been shown to play a role in forming an inflammasome in response to specific infections, and it can also function as a regulator of inflammatory signaling.
NLRP12 gene - MedlinePlus
At least 20 variants (also known as mutations) in the NLRP12 gene have been found to cause familial cold autoinflammatory syndrome type 2. This condition causes episodes of fever, skin rash, and joint pain, often in response to cold temperatures.
The role of NLRP12 in inflammatory diseases - ScienceDirect
Oct 5, 2023 · NLRP12 and pathogenic infections are closely linked, and alterations in NLRP12 expression and activity are associated with inflammatory diseases. In this review, we begin with a summary of the mechanisms of negative regulation by NLRP12.
NLRP12 gene mutations and auto-inflammatory diseases: ever-changing ...
Jul 28, 2020 · Patients with NLRP12 variants develop a rare autosomal dominant condition known as familial cold-induced autoinflammatory syndrome (FCAS2, OMIM #611762) that has been related to several different clinical manifestations including autoimmunity and …
NLRP12 in Innate Immunity and Inflammation - PMC - PubMed …
NLRP12 is a member of the NLR family that contains an N-terminal pyrin domain, a central nucleotide-binding domain, and a C-terminal leucine-rich repeat. It has been shown to play a role in forming an inflammasome in response to specific infections, and it can also function as a regulator of inflammatory signaling.
NLRP12 Gene - GeneCards | NAL12 Protein | NAL12 Antibody
Oct 2, 2024 · NLRP12 (NLR Family Pyrin Domain Containing 12) is a Protein Coding gene. Diseases associated with NLRP12 include Familial Cold Autoinflammatory Syndrome 2 and Familial Cold Autoinflammatory Syndrome 3. Among its related pathways are SARS-CoV-2 Infection and Infectious disease.
The NLR gene family: from discovery to present day
Mar 27, 2023 · Cell-specific regulation of inflammation by NLRP12. NLRP12 is expressed in different myeloid cell populations, with prominent expression in granulocytes and dendritic cells 213. NLRP12...
NLRP12 NLR family pyrin domain containing 12 [ (human)]
Oct 28, 2024 · NLRP12 Senses the SARS-CoV-2 Membrane Protein and Promotes an Inflammatory Response. NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. The contributions of deleterious rare alleles in NLRP12 and inflammasome-related genes to polymyalgia rheumatica.
NLRP12 interacts with NLRP3 to block the activation of the
Jan 23, 2024 · We first investigated whether NLRP12 directly interacted with NLRP3 by coexpressing human NLRP3 with human full-length NLRP12, a mutant NLRP12 without its LRR domain (N12ΔLRR, representing the NLRP12 patient mutation V635ThrfsX12), or the Walker AB mutant NLRP12 and then immunoprecipitating NLRP3.