Neuroligin - Wikipedia
Neuroligin is a type I membrane protein that mediates the formation and maintenance of synapses between neurons. It binds to β-neurexin on the presynaptic membrane and interacts with other postsynaptic proteins to regulate synaptic functions and signalling.
Neuroligins and neurexins link synaptic function to cognitive …
Oct 15, 2008 · Neurexins and neuroligins are synaptic cell-adhesion molecules that connect presynaptic and postsynaptic neurons at synapses, mediate signalling across the synapse, and shape the properties...
Neuroligins and Neurexins Link Synaptic Function to Cognitive Disease
Neurexins and neuroligins are synaptic cell-adhesion molecules that connect pre- and postsynaptic neurons at synapses, mediate trans-synaptic signaling, and shape neural network properties by specifying synaptic functions.
Roles of neuroligins in central nervous system ... - BioMed Central
Sep 10, 2022 · Neuroligins are postsynaptic cell adhesion molecules that interact with presynaptic neurexins and regulate synaptogenesis and synaptic function. This review focuses on the roles of neuronal and glial neuroligins in the brain and their involvement in neurodevelopmental disorders such as autism and schizophrenia.
Neuroligin-2 as a central organizer of inhibitory synapses in …
Neuroligin-2 (NLGN2) is the only member that acts exclusively at GABAergic inhibitory synapses. Altered expression and mutations in NLGN2 and several of its interacting partners are linked to cognitive and psychiatric disorders, including schizophrenia, autism, and anxiety.
The neuroligins and their ligands: from structure to function …
The neuroligins are cell adhesion proteins whose extracellular domain belongs to the α/β-hydrolase fold family of proteins, mainly containing enzymes and exemplified by acetylcholinesterase.
Astrocytic neuroligins control astrocyte morphogenesis and ...
Nov 9, 2017 · The neuroligin family cell adhesion proteins NL1, NL2, and NL3, which are expressed by cortical astrocytes, control astrocyte morphogenesis through interactions with neuronal neurexins.
Neuroligin 2 governs synaptic morphology and function through …
Oct 18, 2023 · Neuroligins are transmembrane cell adhesion proteins well-known for their genetic links to autism spectrum disorders. Neuroligins can function by regulating the actin cytoskeleton, however...
The cellular and molecular landscape of neuroligins - Cell Press
Jul 21, 2015 · Neuroligins are postsynaptic cell adhesion molecules that bind to neurexins across the synaptic cleft. This review covers the conservation, subcellular localization, intermolecular interactions, and molecular modifications of neuroligins, as well as their roles in …
Neuroligin - an overview | ScienceDirect Topics
Neuroligin is a transmembrane protein located at post-synapses that serves as a connection point between pre-synaptic neurexin and post-synaptic proteins, playing a crucial role in regulating the structure and function of synaptic junctions. AI generated definition based on: Progress in Molecular Biology and Translational Science, 2020