Protein neddylation and its role in health and diseases
WEBApr 5, 2024 · NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate through a process...
Neddylation: a novel modulator of the tumor microenvironment
WEBApr 3, 2019 · Neddylation is a process of conjugating NEDD8, an ubiquitin-like molecule, to targeted protein substrates via enzymatic cascades involving NEDD8-activating enzyme E1, NEDD8-conjuagating enzyme E2 and substrate-specific NEDD8-E3 ligases. Shown are reported neddylation E1/E2s/E3s and substrates.
Neddylation: a novel modulator of the tumor microenvironment
WEBApr 3, 2019 · Neddylation, a post-translational modification that adds an ubiquitin-like protein NEDD8 to substrate proteins, modulates many important biological processes, including tumorigenesis.
Deciphering the role of neddylation in tumor microenvironment ...
WEBJan 8, 2024 · Neddylation is a post-translational modification process, similar to ubiquitination, that controls several biological processes. Notably, it is often aberrantly activated in neoplasms and plays a critical role in the intricate dynamics of the tumor microenvironment (TME).
Protein neddylation: beyond cullin–RING ligases - Nature
WEBDec 22, 2014 · We describe the biological processes that might be regulated by non-cullin neddylation, and the utility of neddylation inhibitors for research and as potential therapies.
Neddylation - Latest research and news | Nature
WEBAug 13, 2024 · Neddylation is a post-translational modification process. It is analogous to ubiquitylation in terms of reaction scheme and enzyme classes used, but neddylated proteins are modified with...
Protein neddylation and its alterations in human cancers for …
WEBNeddylation, a post-translational modification that conjugates an ubiquitin-like protein NEDD8 to substrate proteins, is an important biochemical process that regulates protein function.
Function and regulation of protein neddylation. ‘Protein …
WEBSep 19, 2008 · Neddylation is the post-translational protein modification that is most closely related to ubiquitination. However, ubiquitination is known to regulate a myriad of processes in eukaryotic cells, whereas only a limited number of neddylation substrates have been described to date.
Neddylation - an overview | ScienceDirect Topics
WEBNeddylation is a post-translational modification that transfers NEDD8 to substrate proteins via a cascade of enzymes. Learn how neddylation regulates various biological processes and its role in human cancers, especially gastric cancer.
Diverse and pivotal roles of neddylation in metabolism and …
WEBIntroduction. Neddylation is a revisable post-translational modification by covalently adding a ubiquitin-like molecule neuronal precursor cell-expressed developmentally …
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