Mucin - Wikipedia
Mucins (/ ˈmjuːsɪn /) are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most animals. [1] .
Mucin - an overview | ScienceDirect Topics
Mucins are a family of high molecular weight, heavily glycosylated proteins that are classified into 2 groups: membrane-bound mucins (eg, MUC1, MUC3, and MUC4) involved in signal transduction and gel-forming secreted mucins released into the extracellular space (eg, MUC2, MUC5AC, MUC5B and MUC6). 1 At least 18 mucin genes have been cloned to ...
Mucins in cancer: function, prognosis and therapy - PMC
The mucins function in limiting the activation of inflammatory responses at the interface with the environment. Deregulation of mucin production has therefore provided an important link between inflammation and cancer.
Mucins in cancer: function, prognosis and therapy - Nature
Recent work has demonstrated that the MUC1 cytoplasmic domain is a direct drug target and that inhibition of MUC1 function blocks survival and tumorigenicity of human breast and prostate...
Mucins: Structural diversity, biosynthesis, its role in …
Feb 1, 2018 · Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins.
Mucins in Intestinal Mucosal Defense and Inflammation: Learning …
Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly glycosylated proteins called mucins plays an essential role in providing lubrication for the passage of food, participating in cell signaling pathways and protecting the host epithelium from commensal microorganisms and invading pathogens, as well as toxins and...
Mucins and the Microbiome - PMC - PubMed Central (PMC)
Sep 21, 2021 · Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two flavors, gel-forming and transmembrane, all characterized by large highly O-glycosylated mucin ...
Mucus: Current Biology - Cell Press
Aug 9, 2021 · In this Primer, we will take a look at how mucins, the building blocks of mucus, are synthesized, how their expression is regulated and achieved, and how they make crucial contributions to health and disease.
Immunological aspects of intestinal mucus and mucins
Aug 8, 2016 · In this Review, we will give a basic overview of mucus, mucins and goblet cells, and explain how each of these contributes to immune regulation in the intestine. Our bodies are continuously exposed...
Mucins in the mucosal barrier to infection | Mucosal Immunology
Mar 5, 2008 · In this review, we highlight the central role played by mucins in accommodating the resident commensal flora and limiting infectious disease, interplay between underlying innate and adaptive...