Mucin - Wikipedia
Increased mucin production occurs in many adenocarcinomas, including cancers of the pancreas, lung, breast, ovary, colon and other tissues.
Mucin - an overview | ScienceDirect Topics
Mucins are a family of high molecular weight, heavily glycosylated proteins that are classified into 2 groups: membrane-bound mucins (eg, MUC1, MUC3, and MUC4) involved in signal transduction and gel-forming secreted mucins released into the extracellular space (eg, MUC2, MUC5AC, MUC5B and MUC6). 1 At least 18 mucin genes have been cloned to ...
Mucins: a biologically relevant glycan barrier in mucosal …
Mucins are modified in a variety of diseases and this may be due to abberant mucin peptide or glycosylation. Major conclusions: Mucins represent a family of glycoprotein having fundamental roles in mucosal protection and communication with external environment.
Immunological aspects of intestinal mucus and mucins
Aug 8, 2016 · Mucins are highly O -glycosylated molecules that have gel-like properties. The mucin family consists of transmembrane mucins and gel-forming mucins. The transmembrane mucins cover the...
Mucins in cancer: function, prognosis and therapy - Nature
Secreted mucins are highly glycosylated proteins that form a physical barrier, which protects epithelial cells from stress-induced damage. Transmembrane mucins also contribute to the physical...
Mucus: Current Biology - Cell Press
Aug 9, 2021 · Mucins are a family of polymers with complex glycan modifications that underpin the mucus gel.
Mucus: Phlegm, Causes, Colors & How To Get Rid Of It - Cleveland …
Sep 20, 2024 · Mucin, a type of protein that gives mucus its gel-like consistency. What does mucus look like? Mucus is usually clear, thin and slippery. If you have a respiratory or sinus infection, the mucus coming out of your nose or throat may be thick, sticky and creamy white.
Mucins: Structural diversity, biosynthesis, its role in …
Feb 1, 2018 · Mucins are the main structural components of mucus that create a selective protective barrier for epithelial surface and also execute wide range of other physiological functions. Mucins can be classified into two types, namely secreted mucins and membrane bounded mucins.
The biology of mucus: Composition, synthesis and organization
Jan 15, 2018 · The major structural and functional component, mucin is a complex glycoprotein coded by about 20 mucin genes which produce a protein backbone having multiple tandem repeats of Serine, Threonine (ST repeats) where oligosaccharides are covalently O-linked.
Revealing the human mucinome | Nature Communications
Jun 20, 2022 · Mucin domains are densely O-glycosylated modular protein domains found in various extracellular and transmembrane proteins. Mucin-domain glycoproteins play important roles in many human...