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  1. Wikipedia
    https://en.wikipedia.org/wiki/5-Methylcytosine

    5-Methylcytosine - Wikipedia

    • 5-Methylcytosine is a methylated form of the DNA base cytosine (C) that regulates gene transcription and takes several other biological roles. When cytosine is methylated, the DNA maintains the same sequence, but the expression of methylated genes can be altered (the study of this is part of the field of epigenetics). 5-Methylcytosine is incorpor… See more

    Discovery

    While trying to isolate the bacterial toxin responsible for tuberculosis, W.G. Ruppel isolated a novel nucleic acid named See more

    In vivo

    The function of this chemical varies significantly among species:
    • In bacteria, 5-methylcytosine can be found at a variety of sites, and is often used as a marker to protect DNA from being cut by native meth… See more

    In vitro

    The NH2 group can be removed (deamination) from 5-methylcytosine to form thymine with use of reagents such as nitrous acid; cytosine deaminates to uracil (U) under similar conditions.
    5-methylcyt… See more

    Advances in RNA cytosine-5 methylation: detection, regulatory ...
    As an important posttranscriptional modification of RNA, 5-methylcytosine (m 5 C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m …
    Biomarker Research · https://biomarkerres.bio…
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    In vivo
    In vitro
     
  1. Studies of Methyl C
    National Center for Biotechnology Information
    MethylC-analyzer: a comprehensive downstream pipeline for the analysis of genome-wide DNA methylation
    DNA methylation is a crucial epigenetic modification involved in multiple biological processes and diseases. Current approaches for measuring genome-wide DNA methylation via bisulfite sequencing (BS-seq) include whole-genome bisulfite sequencing (WGBS), reduced representation bisulfite sequencing (R...
    Author: Rita Jui-Hsien …
    Published: 2023/12
    Publication: Bot Stud. …
    National Center for Biotechnology Information
    Advances in mRNA 5-methylcytosine modifications: Detection, effectors, biological functions, and clinical relevance
    Since the discovery of the first post-transcriptional RNA modification, pseudouridine (ψ), in the 1950s,1 researchers have explored the mechanisms underlying gene regulation at the RNA level. This emerging field has been designated as “RNA epigenetics” or “epitranscriptomics.”2, 3, 4 Compared with t...
    Author: Gangqiang Gu…
    Published: 2021/12/12
    Publication: Mol Ther …
    PubMed
    MethylC-seq library preparation for base-resolution whole-genome bisulfite sequencing
    Current high-throughput DNA sequencing technologies enable acquisition of billions of data points through which myriad biological processes can be interrogated, including genetic variation, chromatin structure, gene expression patterns, small RNAs and protein-DNA interactions. Here we describe the M...
    Author: Mark A Urich
    Published: 2015/3
    Keywords: National In…
    ResearchGate
    MethylC-analyzer: a comprehensive downstream pipeline for the analysis of genome-wide DNA methylation
    DNA methylation is a crucial epigenetic modification involved in multiple biological processes and diseases. Current approaches for measuring genome-wide DNA methylation via bisulfite sequencing (BS-seq) include whole-genome bisulfite sequencing (WGBS), reduced representation bisulfite sequencing (R...
    Published: 2023/01/06
    DOI: 10.1186/s40529-0…
  2. Nature
    https://www.nature.com/articles/nprot.2014.114

    MethylC-seq library preparation for base-resolution whole …

  3. Nature
    https://www.nature.com/articles/npp2012112

    DNA Methylation and Its Basic Function

  4. PubChem
    https://pubchem.ncbi.nlm.nih.gov/compoun…

    5-Methylcytosine | C5H7N3O | CID 65040 - PubChem

    5-methylcytosine is a pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position. It has a role as a human metabolite. It is a member of pyrimidines and a methylcytosine. It is functionally related to a cytosine. ChEBI.

  5. ScienceDirect
    https://www.sciencedirect.com/.../5-methylcytosine

    5-Methylcytosine - an overview | ScienceDirect Topics

  7. nih.gov
    https://pmc.ncbi.nlm.nih.gov/articles/PMC9428128

    5-methylcytosine turnover: Mechanisms and therapeutic …

  8. Nature
    https://www.nature.com/articles/s41592-01…

    Simultaneous profiling of 3D genome structure and …

    Sep 9, 2019 · Single-nucleus methyl-3C sequencing jointly interrogates 3D chromatin organization and DNA methylation in human cells, and these joint measurements more accurately distinguish different cell...

  9. BMC Bioinformatics
    https://bmcbioinformatics.biomedcentral.com/...

    msPIPE: a pipeline for the analysis and visualization of whole …

  10. Biomarker Research
    https://biomarkerres.biomedcentral.com/…

    Advances in RNA cytosine-5 methylation: detection, …

    Sep 14, 2020 · As an important posttranscriptional modification of RNA, 5-methylcytosine (m 5 C) has attracted increasing interest recently, with accumulating evidence suggesting the involvement of RNA m 5 C modification …

  11. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823188

    MethylC-analyzer: a comprehensive downstream pipeline for the …