Melatonin - Wikipedia
Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of …
Melatonin | C13H16N2O2 | CID 896 - PubChem
Melatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. In mammals, melatonin is produced by the pineal gland.
Melatonin and Phytomelatonin: Chemistry, Biosynthesis, …
Chemical structure of melatonin. Moreover, the 3-amide group and 5-alkoxygroup are also the main responsible of the amphiphilicity of this molecule. This property makes melatonin able to cross biological membranes and enter any cellular and subcellular compartments [ 36 , 37 ], allowing not only its easy distribution but also a high protection ...
Melatonin | Description, Hormone, & Effects | Britannica
Oct 30, 2024 · melatonin, hormone secreted by the pineal gland, a tiny endocrine gland situated at the center of the brain. Melatonin was first isolated in 1958 by American physician Aaron B. Lerner and his colleagues at Yale University School of Medicine.
Physiology of the Pineal Gland and Melatonin
Oct 30, 2022 · Melatonin Target Sites and Receptors. Melatonin’s target sites are both central and peripheral. Binding sites have been found in many areas of the brain, including the pars tuberalis and hypothalamus, but also in the cells of the immune system, gonads, kidney, and the cardiovascular system (39, 40).
Melatonin: Pharmacology, Functions and Therapeutic Benefits
In addition, effects of melatonin on body mass and bone mass regulation have been reported. Melatonin is known for its role in energy expenditure and body mass regulation in mammals by preventing the increase in body fat with age [81 - 83]. These effects are mediated by MT2 receptors in adipose tissue [84].
Melatonin: Current Biology - Cell Press
Nov 22, 2021 · In humans it is a small ‘pea-sized’ structure located in the middle of the brain, and was thought by René Descartes (1596–1650) to be the anatomical location of the soul. This remains unproven. In all mammals, the pineal is an endocrine organ releasing melatonin.
Melatonin | C13H16N2O2 - ChemSpider
ChemSpider record containing structure, synonyms, properties, vendors and database links for Melatonin, 73-31-4, 205542.
Melatonin - NIST Chemistry WebBook
Jun 5, 2010 · Melatonin. Formula: C 13 H 16 N 2 O 2. Molecular weight: 232.2783. IUPAC Standard InChI: InChI=1S/C13H16N2O2/c1-9 (16)14-6-5-10-8-15-13-4-3-11 (17-2)7-12 (10)13/h3-4,7-8,15H,5-6H2,1-2H3, (H,14,16) IUPAC Standard InChIKey: DRLFMBDRBRZALE-UHFFFAOYSA-N. CAS Registry Number: 73-31-4. Chemical structure:
Melatonin’s role in the timing of sleep onset is conserved
Nov 1, 2024 · Melatonin supplementation strengthens non‐restorative sleep rhythms and its temporal alignment in both humans and night-active rodents. Of note, although the sleep cycle is reversed in day ...