Histological regression in melanoma: impact on sentinel lymph …
Jul 10, 2021 · Regression in melanoma is an immunological phenomenon that results in partial or complete replacement of the tumor with variably vascular fibrous tissue, often accompanied by pigment-laden...
Regression in Melanoma - WebPathology
The clinical significance of regression in melanomas has been controversial. Some authors believe that it indicates better prognosis, whereas others have suggested that it increases the likelihood of metastases.
Regression in primary cutaneous melanoma: etiopathogenesis …
Feb 27, 2017 · In this review, we discuss the various definitions and measurements of melanoma regression, the potential value of regression as a prognostic parameter, and the possible biologic mechanisms ...
Regression in primary cutaneous melanoma: etiopathogenesis …
Jun 1, 2017 · In this review, we discuss the various definitions and measurements of melanoma regression, the potential value of regression as a prognostic parameter, and the possible biologic mechanisms contributing to regression with the goal to promote the need for more standardized criteria for histologic assessment of regression.
Pathology Outlines - Regressed melanoma (tumoral melanosis)
Nov 27, 2023 · Regressed melanoma can present clinically by initially subtle hyperpigmentation, followed by depigmentation of parts of or the entirety of the lesion yielding blue, pink, white or gray areas. Histopathology is characterized by dense, dermal melanophage infiltrate but no …
Regression in cutaneous melanoma: histological assessment, …
In primary cutaneous melanoma, a disease known for its poor prognosis in advanced stages, the significance of regression has been investigated from a number of standpoints during the past several decades, generating a lively and oftentimes contentious discourse in …
Extensive regression in pigmented skin lesions: a dangerous …
Spontaneous regression in melanomas is not an uncommon phenomenon, as it has been described in 10–35% of primary cutaneous lesions [1]. Regression does not appear to predict a more favorable course, since even fully regressed melanomas may progress into …
In primary cutaneous melanoma, a disease known for its poor prognosis in advanced stages, the signicance of regression has been fi investigated from a number of standpoints during the past several decades, generating a lively and oftentimes conten-tious discourse in …
Histological regression in melanoma: impact on sentinel lymph …
This study sought to determine whether regression in primary cutaneous melanomas predicted sentinel lymph node (SLN) status and survival outcomes in a large cohort of patients managed at a single centre.
Association of Histologic Regression With a Favorable Outcome in ...
Subgroup analyses showed that regression was significantly associated with improved recurence-free survival for patients with thin and intermediate Breslow thickness melanomas (≤4.0 mm), and for those with superficial spreading melanoma (SSM) subtype.
Regression and Sentinel Lymph Node Status in Melanoma …
Histological regression was found in 37 cases of melanoma (21.3%). It was significantly associated with marked and moderate tumor-infiltrating lymphocyte (TIL) and with negative SLN. Progression of the disease occurred in 42 patients (24.2%).
Regression in cutaneous melanoma: a comprehensive review …
Histological regression in primary cutaneous melanoma occurs in 10-35% of cases. Although a large body of literature exists to suggest that histological regression serves very little purpose in predicting biologic behaviour with melanoma, recognizing the presence of …
Characterizing regression in melanomas: A population-based study
Regressing melanomas are characterized by generally better prognostic factors than other malignant melanomas, and have better survival overall. Regression may represent a strengthened immune response to tumor.
Regression in Primary Melanomas: Histologic Factors and Prognosis
Despite advances in research and treatment, the prognosis of melanoma in many ways remains an anomaly. A number of histologic factors are thought to play a role, and one pointed area of debate in recent years has been the role of regression in primary melanoma.
Regression in cutaneous melanoma: histological assessment, …
Sustained progress in unravelling the pathogenesis of melanoma regression has led to the identification of therapeutic targets, culminating in the development of immune checkpoint inhibitors for the management of advanced disease.
Primary Melanoma Histologic Regression and Sentinel Lymph Node Status
In this systematic review and meta-analysis including 14 studies 8,18-30 and more than 10 000 patients, we found that histologic regression is a protective factor for SLN-positive status: patients with melanoma and regression had a lower likelihood of SLN positivity (OR, 0.56; 95% CI, 0.41-0.77) than patients without regression.
Regression is significantly associated with outcomes for …
Nov 1, 2021 · The prognostic significance of regression in melanoma is debated. We present a large multicenter study correlating regression with sentinel lymph node metastasis and melanoma-specific survival.
Regression in cutaneous melanoma: histological assessment, …
Mar 1, 2023 · The progressive accumulation of clinical, pathological, and immunological data, as well as technological advancement, have led to important breakthroughs in our understanding of regression in melanoma that have informed the pathobiology, prognostication, and management of this unpredictable disease.
Regression is significantly associated with outcomes for …
This large study shows that regression is significantly associated with better outcomes in patients with melanoma and is correlated with a lower risk of sentinel lymph node metastasis and a better melanoma-specific survival.
Diagnosis and prognosis of melanoma from dermoscopy images …
Jan 13, 2025 · Melanoma is a highly aggressive skin cancer, where early and accurate diagnosis is crucial to improve patient outcomes. Dermoscopy, a non-invasive imaging technique, aids in melanoma detection but can be limited by subjective interpretation. ... Logistic regression (LR) is particularly suitable for classifying binary problems and is often used ...
Can a Melanoma Mole Spontaneously Disappear or Regress?
Yes, there is always a chance that a melanoma can spontaneously regress or start disappearing. This type of melanoma is especially dangerous because usually, it's diagnosed at a later stage.
CD133 + PD-L1 + cancer cells confer resistance to adoptively
4 days ago · B16F10 cells (5 × 10 5) and A375 cells (5 × 10 6) were suspended in 50 μl of PBS and s.c. injected into the left flank of mice to establish C57BL/6 mice bearing mouse B16F10 melanoma model and ...
Prognostic value and immune infiltration of a tumor …
Dec 28, 2024 · Background Cutaneous melanoma is one of the most invasive and lethal skin malignant tumors. Compared to primary melanoma, metastatic melanoma (MM) presents poorer treatment outcomes and a higher mortality rate. The tumor microenvironment (TME) plays a critical role in MM progression and immunotherapy resistance. This study focuses on the role …
Reflecting on a Decade of Progress and Future Heights in Melanoma
Jul 21, 2023 · Many shied away from melanoma at pivotal points in their training and careers; Wolchok himself was actively discouraged from specializing in the field. ... enabling patients to take pills at home and experience disease regression, and; Personalized T-cell adoptive transfer (i.e., isolation and reinfusion of T-cells into patients), which is ...