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  1. The MYC oncogene — the grand orchestrator of cancer growth

    • The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related … See more

    Key points

    •The MYC oncogene is activated in the vast majority of cancers by genetic, epigenetic or … See more

    Nature
    Introduction

    The MYC oncogene (also known as c-MYC) is part of a superfamily of genes with products that are among the most commonly activated in human cancers1,2,… See more

    Nature
    MYC is often activated in human cancers

    Genetic alterations affecting the MYC proto-oncogenes and the MYC-related signalling pathways are among the most common in human cancers1,2,3,4 (Fig. 1). MYC can b… See more

    Nature
    MYC oncogene addiction

    In 2002, Bernard Weinstein proposed that cancers are ‘oncogene addicted’27 following evidence from both experimental mouse models of MYC-driven cancers and clinical stud… See more

    Nature
    Mechanisms of host immune evasion

    MYC activation in cancer cells can impede the host immune response. Conversely, its inactivation seems to restore antitumour immunity in a sequential manner. In an experiment… See more

    Nature
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  1. Studies of MYC Tumor
  2. The effects of MYC on tumor immunity and immunotherapy

  3. MYC protein interactors in gene transcription and cancer

  4. MYC as a target for cancer treatment - PubMed

  5. MYC on the path to cancer - PubMed

  6. MYC as a target for cancer treatment

  7. Targeting oncogenic Myc as a strategy for cancer treatment

  8. A big step for MYC-targeted therapies: Trends in …

    Apr 4, 2024 · MYC is the most commonly activated oncogene in human cancer [1,2]. It drives tumorigenesis through direct regulation of the hallmarks of cancer including cellular proliferation, self-renewal, differentiation, survival/apoptosis, …

  9. The MYC oncogene - the grand orchestrator of cancer growth and …

  10. MYC on the Path to Cancer - Cell Press

    The MYC oncogene contributes to the genesis of many human cancers. Recent insights into its expression and function have led to therapeutic opportunities. MYC's activation by bromodomain proteins could be inhibited by drug-like …

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