MUC5B Gene - GeneCards | MUC5B Protein | MUC5B Antibody
Oct 2, 2024 · MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5B include Interstitial Lung Disease 2 and Extrinsic Allergic Alveolitis. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins. An important paralog of this gene is FCGBP.
Muc5b overexpression causes mucociliary dysfunction and
Dec 18, 2018 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a...
MUC5B mobilizes and MUC5AC spatially aligns mucociliary
Nov 25, 2022 · Airway mucus is composed of two mucins: mucin 5B (MUC5B) and 5AC (MUC5AC). Together, they form a hydrogel that can be actively transported by cilia along the airway surface. In chronic respiratory diseases, abnormal expression of these mucins is directly implicated in dysfunctional mucus clearance.
Muc5b is required for airway defence - Nature
Dec 8, 2013 · Here we show that mouse Muc5b (but not Muc5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac...
MUC5B - The New England Journal of Medicine
Oct 20, 2018 · The common gain-of-function variant rs35705950 16 in the promoter of MUC5B, encoding mucin 5B, is the strongest genetic risk factor for idiopathic pulmonary fibrosis; it is observed in at least...
The MUC5B mucin polymer is dominated by repeating structural …
Nov 22, 2019 · The polymeric mucin MUC5B provides the structural and functional framework of respiratory mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective barrier.
MUC5B and Idiopathic Pulmonary Fibrosis - PMC - National …
Mar 1, 2015 · Expression of MUC5B is also highly correlated with expression of cilium genes in IPF lung. Our work suggests that mucociliary dysfunction in the distal airway may play a role in the development of progressive fibroproliferative lung disease.
MUC5B mucin 5B, oligomeric mucus/gel-forming [ (human)]
Sep 17, 2024 · MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR mutations but not for patients with NSCLC carrying wild-type EGFR; MUC5B has recently been shown to be associated with idiopathic pulmonary fibrosis susceptibility and survival.
Muco-Obstructive Lung Diseases | New England Journal of …
May 15, 2019 · The two major synthesized and secreted respiratory mucins, MUC5B and MUC5AC, are physically very large, spanning 0.2 to 10 μm in length for single polymers.
Muc5b overexpression causes mucociliary dysfunction and …
Dec 18, 2018 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF.
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