Cell permeability inhibitors such as protein transduction domain MUC1 inhibitory peptide (PMIP), which interfere with MUC1-EGFR interactions, have been extensively developed and shown to …

Dec 1, 2020 · Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild …

Nov 6, 2018 · Redesign of the vaccine focusing on the protective epitope led to a new Qβ-MUC1 construct, which was capable of inducing higher levels of anti-MUC1 IgG antibodies in …

Feb 9, 2024 · To simulate the aberrantly glycosylated MUC1 glycoprotein, the MUC1 tandem repeat peptide was bounded with Tn antigens at T9, S15, and T16, and served as B-cell …

Secreted and transmembrane mucins form a protective mucous barrier, and transmembrane mucins may also function in signaling the presence of adverse conditions in the extracellular …

The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor …

This phase I clinical trial revealed the safety of a vaccine containing 100-mer MUC1 peptides and incomplete Freund's adjuvant.

Nov 1, 2022 · MUC1-C→E2F1→BRG1 signaling modulates prostate CSC status by integrating crosstalk between esBAF and PBAF pathways. MUC1-C plays a pivotal role in the interaction …

Jan 20, 2016 · The efficacy of MUC1 peptides to develop MUC1-specific CD4 + and CD8 + T-cell responses was examined in MUC1.Tg and C57BL/6 wild type (WT) mice. The transgenic mice …

Jan 8, 2014 · MUC1’s signal peptide (SP) domain promiscuously binds multiple MHC class II and Class I alleles, which upon vaccination, generated robust T-cell immunity against MUC1 …