MUC1: Structure, Function, and Clinic Application in ... - PubMed
Jun 18, 2021 · The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in normal cells.
MUC1: Structure, Function, and Clinic Application in Epithelial …
The transmembrane glycoprotein mucin 1 (MUC1) is a mucin family member that has different functions in normal and cancer cells. Owing to its structural and biochemical properties, MUC1 can act as a lubricant, moisturizer, and physical barrier in ...
Muc1: a multifaceted oncoprotein with a key role in cancer …
Mucin 1 (MUC1; also known as episialin, PEM, H23Ag, EMA, CA15-3, and MCA) is a single pass type I transmembrane protein with a heavily glycosylated extracellular domain that extends up to 200–500 nm from the cell surface [1, 2].
MUC1 Gene - GeneCards | MUC1 Protein | MUC1 Antibody
Oct 2, 2024 · MUC1 (Mucin 1, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC1 include Tubulointerstitial Kidney Disease, Autosomal Dominant, 2 and Muc1-Related Autosomal Dominant Tubulointerstitial Kidney Disease. Among its related pathways are O-linked glycosylation of mucins and Metabolism of proteins.
MUC1: a multifaceted oncoprotein with a key role in cancer
This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1. We also discuss the recent advances made in the use of MUC1 as a biomarker and therapeutic target for cancer.
MUC1 gene - MedlinePlus
The MUC1 gene provides instructions for making a protein called mucin 1. This protein is one of several mucin proteins that make up mucus, a slippery substance that lubricates and protects the lining of the airways, digestive system, reproductive system, and other organs and tissues.
Mucins in cancer: function, prognosis and therapy - Nature
Recent work has demonstrated that the MUC1 cytoplasmic domain is a direct drug target and that inhibition of MUC1 function blocks survival and tumorigenicity of human breast and prostate...
MUC1 mucin 1, cell surface associated [ (human)] - National …
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling.
Expression of MUC1 in different tumours and its clinical …
Mucin 1 (MUC1) was the first discovered transmembrane protein of the mucin family; it normally covers epithelial cells of the mucous membrane, providing lubrication and protection. However, aberrant expression of MUC1 is involved in cancer development, invasion and metastasis.
Glycosylated modification of MUC1 maybe a new target to
Aug 16, 2022 · MUC1 is a highly glycosylated transmembrane protein, overexpressed in breast cancer, contributing to tumorigenesis and worse prognosis.
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