The mannose 6-phosphate receptors (MPRs) are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates. [1] Mannose 6-phosphate receptors bind newly synthesized lysosomal hydrolases in the trans-Golgi network (TGN) and deliver them to …

The cation-independent mannose 6-phosphate receptor is a multifunctional protein which binds at the cell surface to two distinct classes of ligands, the mannose 6-phosphate (M6P) bearing proteins and IGF-II. Its major function is to bind and ...

Mar 1, 2003 · The two mannose 6-phosphate (M6P) receptors were identified because of their ability to bind M6P-containing soluble acid hydrolases in the Golgi and transport them to the...

Apr 1, 2012 · This role is carried out by the mannose-6-phosphate receptors (MPRs), which are type I transmembrane glycoproteins that bind their specific oligosaccharide at pH 6,5-6,7, in the trans-Golgi network and release it at pH 6, the typical pH inside late endosomes.

The M6P groups are then recognized by two independent transmembrane M6P receptors, present in the trans-Golgi network: the cation-independent M6P receptor and/or the cation-dependent M6P receptor. These proteins bind to lysosomal hydrolases on the lumenal side of the membrane and to adaptins in assembling clathrin coats on the cytosolic side.

Mannose-6-phosphate is an N-linked oligosaccharide generated by enzymes present in the cis-Golgi cisterna. It is formed specifically on proteins destined for the lysosome. The mannose-6-phosphate receptor spans the Golgi membrane and binds to coat proteins on the cytosolic side of the membrane and to the mannose-6-phosphate-containing protein ...

Jan 1, 2024 · The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose 6-phosphate moieties to lysosomal compartments.

Mannose 6-phosphate (M6P) is a specialized carbohydrate structure found on lysosomal enzymes. M6P enables newly synthesized lysosomal enzymes to bind to M6P receptors in Golgi for delivery of the lysosomal enzymes to lysosome within cells.

The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for transport to the lysosome. Homologues of CD-MPR are found in all eukaryotes.

May 16, 2018 · M6PR is primarily distributed intracellularly with only a fraction displayed at the cell surface. 8 M6PR is a versatile receptor involved in several biological processes, including protein...