Lysosome-targeting chimaeras for degradation of extracellular ... - Nature
WEBJul 29, 2020 · These initial lysosome-targeting chimaeras, which we term LYTACs, consist of a small molecule or antibody fused to chemically synthesized glycopeptide ligands that are agonists of the...
LYTACs that engage the asialoglycoprotein receptor for ... - Nature
WEBMar 25, 2021 · The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor...
Targeted protein degradation: mechanisms, strategies and …
WEBApr 4, 2022 · LYTAC is a novel technique to induce the degradation of extracellular and membrane proteins via the endosome-lysosome pathway 81,82 (Fig. 7). As extracellular and membrane proteins comprise 40%...
Lysosome‐targeting chimera (LYTAC): A silver bullet for targeted ...
WEBJan 14, 2024 · Lysosome-targeting chimera (LYTAC): A silver bullet for targeted degradation of oncogenic membrane proteins. Qingquan Zheng, Jiawei Guo, Rui Ma, Wenchen Pu. First published: 14 January 2024. https://doi.org/10.1002/mog2.64.
LYTACs: An Emerging Tool for the Degradation of Non-Cytosolic
WEBOct 6, 2021 · LYTACs are specifically meant for the degradation of membrane-bound and extracellular proteins, which account for the products of 40 % of all protein-encoding genes. In this highlight, we describe two studies that demonstrate the scope of LYTACs and its advantages over the other protein degradation platforms.
Directed evolution of genetically encoded LYTACs for cell …
WEBMar 22, 2024 · Lysosome-targeting chimeras (LYTACs) are a promising therapeutic modality to drive the degradation of extracellular proteins. However, early versions of LYTAC contain synthetic glycopeptides that cannot be genetically encoded.
Major advances in targeted protein degradation: PROTACs, …
WEBApr 9, 2021 · In this review, we discuss the different forms of TPD, highlighting the major advances in proteasomal-, lysosomal-, and autophagy-targeting technologies. We explain the current understanding of the mechanism of each technology and discuss the outstanding questions in each approach.
Elucidating the cellular determinants of targeted membrane …
WEBOct 20, 2023 · Lysosome-targeting chimeras (LYTACs) harness receptors, such as the cation-independent mannose 6-phosphate receptor (CI-M6PR), to direct extracellular proteins to lysosomes. In this work, we used a genome-wide CRISPR knockout approach to identify modulators of LYTAC-mediated membrane protein degradation in human cells.
Targeted degradation of membrane and extracellular proteins with …
WEBAug 5, 2024 · This review delineates the recent progresses of LYTAC technology, its practical applications, and the factors that dictate target degradation efficiency.
Platform & Applications - Lycia Therapeutics
WEBOur proprietary LYTAC—Lysosomal Targeting Chimera—platform enables targeted degradation of the untapped extracellular proteins. Our LYTAC platform is designed to enable the depletion of (versus the inhibition of) of many targets previously considered undruggable, and the development of novel therapeutics for currently underserved …