Lamin - Wikipedia
Lamins, also known as nuclear lamins are fibrous proteins in type V intermediate filaments, providing structural function and transcriptional regulation in the cell nucleus. Nuclear lamins interact with inner nuclear membrane proteins to form the nuclear lamina on the interior of the nuclear envelope.
The lamin protein family | Genome Biology | Full Text
Dec 5, 2011 · The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability.
Lamin A/C: Function in Normal and Tumor Cells - PMC
Dec 9, 2020 · Lamin A/C is a nuclear protein with many functions in cells, such as maintaining a cell’s structural stability, cell motility, mechanosensing, chromosome organization, gene regulation, cell differentiation, DNA damage repair, and telomere protection.
Lamin - an overview | ScienceDirect Topics
Lamins are nuclear intermediate filament proteins and are the principal component of the nuclear lamina, a meshwork of proteins residing just inside the inner nuclear membrane (INM).
Lamins: The backbone of the nucleocytoskeleton interface
Feb 1, 2024 · The nuclear lamina (NL) is a crucial component of the inner nuclear membrane (INM) and consists of lamin filaments and associated proteins. Lamins are type V intermediate filament proteins essential for maintaining the integrity and mechanical properties of the nucleus.
Lamins: the structure and protein complexes - PubMed
Lamins are nuclear intermediate filament (IF) proteins. They assemble to fibrous structures that are positioned between the inner nuclear membrane and the peripheral chromatin. A small fraction of lamins is also present in the nucleoplasm.
Nuclear lamins: Structure and function in mechanobiology - PMC
Feb 1, 2022 · Lamins interact with a wide range of nuclear proteins and are involved in numerous nuclear and cellular functions. Within the nucleus, they play roles in chromatin organization and gene regulation, nuclear shape, size, and mechanics, and the organization and anchorage of nuclear pore complexes.
The lamin protein family - PubMed
Dec 5, 2011 · The lamins are members of the intermediate filament (IF) family of proteins, which constitute a major component of the cytoskeleton. Lamins are the only nuclear IFs and are the ancestral founders of the IF protein superfamily.
The nuclear lamins: flexibility in function - Nature
Dec 5, 2012 · The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, and its functions include attaching chromatin domains to the nuclear periphery and localizing some...
Structural basis for lamin assembly at the molecular level
Aug 21, 2019 · Based on these two interactions, we propose a molecular mechanism for lamin assembly that is in agreement with a recent model representing the native state and could explain pathological...
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