Lymphocyte function-associated antigen 1 - Wikipedia
WEBLymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. [1] LFA-1 plays a key role in emigration, which is the process by which leukocytes leave the bloodstream to enter the tissues. LFA-1 also mediates firm arrest of leukocytes. [2]
Understanding the Role of LFA-1 in Leukocyte Adhesion …
WEBMar 25, 2022 · LFA-1 (Lymphocyte function-associated antigen-1) is a heterodimeric integrin (CD11a/CD18) present on the surface of all leukocytes; it is essential for leukocyte recruitment to the site of tissue inflammation, but also for other immunological processes such as T cell activation and formation of the immunological synapse.
Understanding the Role of LFA-1 in Leukocyte Adhesion
WEBMar 25, 2022 · Absent or dysfunctional expression of LFA-1, caused by mutations in the ITGB2 (integrin subunit beta 2) gene, results in a rare immunodeficiency syndrome known as Leukocyte adhesion deficiency type I (LAD I).
LFA-1 in T cell priming, differentiation, and effector functions
WEBJul 21, 2021 · Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.
LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate …
WEBApr 9, 2019 · LFA-1 and Mac-1 are key integrins that regulate leukocyte adhesion and migration in inflamed tissues. Despite considerable advances in our understanding of leukocyte migration, the...
LFA-1 in T cell priming, differentiation, and effector functions
WEBHighlights. LFA-1 is a mechanosensitive adhesion receptor that couples mechanical forces to fine-tune T cell migration, differentiation, and effector functions. LFA-1 outside-in signaling cascades are coupled to actin dynamics.
LFA-1 in T Cell Migration and Differentiation - PubMed
WEBMay 3, 2018 · Among several leukocyte-specific integrins, lymphocyte function-associated antigen-1 (LFA-1 or α L β 2; CD11a/CD18) is a key T cell integrin, which plays a major role in regulating T cell activation and migration. Adhesion to LFA-1's ligand, intracellular adhesion receptor 1 (ICAM-1) facilitates firm endothelium adhesion, prolonged contact ...
LFA-1 in T Cell Migration and Differentiation - PMC
WEBMay 3, 2018 · Among several leukocyte-specific integrins, lymphocyte function-associated antigen-1 (LFA-1 or α L β 2; CD11a/CD18) is a key T cell integrin, which plays a major role in regulating T cell activation and migration. Adhesion to LFA-1’s ligand, intracellular adhesion receptor 1 (ICAM-1) facilitates firm endothelium adhesion, prolonged contact ...
LFA-1: more than just T cell Velcro | Nature Immunology
WEBNov 1, 2003 · The LFA-1 integrin is known to mediate adhesion between T cells and antigen-presenting cells. New evidence, however, is provided for its role in transmitting signals that promote T cell...
How LFA-1 binds to different ligands: Immunology Today - Cell …
WEBSeveral structural and molecular studies have clarified the contribution of different domains in the α and β subunits of LFA-1 to interact with its ligands ICAM-1, -2 and -3, and have identified important targets for anti-adhesive therapy.