Lymphoid enhancer-binding factor 1 - Wikipedia
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and T cells. It binds to a functionally important site in the T-cell receptor-alpha ( TCRA ) enhancer and confers maximal enhancer activity.
LEF1 Gene - GeneCards | LEF1 Protein | LEF1 Antibody
Oct 2, 2024 · LEF1 (Lymphoid Enhancer Binding Factor 1) is a Protein Coding gene. Diseases associated with LEF1 include Split Hand-Foot Malformation and Ectrodactyly And Ectodermal Dysplasia Without Cleft Lip/Palate.
Wnt signaling pathway protein LEF1 in cancer, as a biomarker for ...
Jun 1, 2017 · Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the Wnt/β-catenin signaling pathway, but can also modulate gene transcription independently.
Tcf1 and Lef1 provide constant supervision to mature CD8
Oct 6, 2021 · Here we show that ablating Tcf1 and Lef1 transcription factors in mature CD8+ T cells aberrantly induces genes from non-T cell lineages.
TCF/LEF family - Wikipedia
Diversity in TCF/LEF protein structure and function comes from having different genes. Humans and jawed vertebrates generally have four genes encoding TCF/LEF proteins: TCF7(also called TCF1) LEF1(also called TCF1α) TCF7L1(also called TCF3) TCF7L2(also called TCF4) Further diversity comes from expression from the same gene of alternative ...
Wnt signaling pathway protein LEF1 in cancer, as a biomarker for ...
Jun 1, 2017 · In this review, we review LEF1 regulation, its role in tumorigenesis in several cancer types, and its clinical value as a biomarker for predicting prognoses and as a target for treatment.
LEF1: a highly specific marker for the diagnosis of chronic
Recently, the role of lymphocyte enhancer-binding factor 1 (LEF1) in CLL was elucidated being highly expressed and seeming to have a prognostic value. Our aim was to test the applicability of LEF1 as marker for CLL in a diagnostic setting.
BMP and WNT signalling cooperate through LEF1 in the neuronal ...
Jun 18, 2018 · Our data point to a mechanistic convergence of the BMP and WNT pathways at the level of the T-cell factor/lymphoid enhancer factor gene Lef1.
LEF1 lymphoid enhancer binding factor 1 [ (human)]
Sep 19, 2024 · This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity.
TCF/LEF Transcription Factors: An Update from the Internet ... - PubMed
Jul 20, 2016 · The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively). The proteins display common structural features and are often expressed in overlapping patterns implying their redundancy.
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