The first kinesins to be discovered were microtubule-based anterograde intracellular transport motors in 1985, … See more

Members of the kinesin superfamily vary in shape but the prototypical kinesin-1 motor consists of two Kinesin Heavy Chain (KHC) molecules which form a protein dimer (molecule pair) that binds two light chains (KLCs), whi… See more

In the cell, small molecules, such as gases and glucose, diffuse to where they are needed. Large molecules synthesised in the cell body, intracellular components such as vesicles and organelles such as mitochondria are … See more

Motor proteins travel in a specific direction along a microtubule. Microtubules are polar; meaning, the heads only bind to the microtubule in one orientation, while ATP binding gives each step its direction through a p… See more

In 2023 direct visualization of kinesin "walking" along a microtubule in real-time was reported. In a "hand-over-hand" mechanism, the kinesin heads step past one another, alternating the lead position. Thus in eac… See more

A number of theoretical models of the molecular motor protein kinesin have been proposed. Many challenges are encountered in theoretical investigations given the remaining uncertainties about the roles of pro… See more