JWH-030 - Wikipedia
JWH-030 is a research chemical which is a cannabinoid receptor agonist. It has analgesic effects and is used in scientific research. It is a partial agonist at CB 1 receptors, with a K i of 87 nM, making it roughly half the potency of THC. It was discovered and named after John W. Huffman.
JWH 030 (CAS 162934-73-8) - Cayman Chem
JWH 030 (Item No. 10831) is a naphthoyl pyrrole cannabimimetic which activates the CB 1 receptor (EC 50 = 30.5 nM for rat, K i = 87 nM for mouse) better than CB 2 (EC 50 = 552 nM for human CB 2). 1, 2 JWH 030 is quite potent in vivo in the mouse spontaneous activity and tail flick (antinociception) assays (ED 50 = 26.8 μM/kg). 2 It also dose ...
Synthetic cannabinoid, JWH-030, induces QT prolongation
Sep 7, 2016 · In the present study, we investigated the effects of synthetic cannabinoids on the cytotoxicity, human Ether-à-go-go-related gene (hERG) channel, action potential duration (APD), and QT interval. The 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that JWH-030 was more cytotoxic than JWH-210, JWH-250, and RCS4 ...
Synthetic cannabinoid, JWH-030, induces QT prolongation …
Nov 1, 2016 · All four of the synthetic cannabinoids (JWH-210, JWH-250, JWH-030, and RCS4) investigated in this study, showed varying levels of cytotoxicity against the H9c2 cell. Particularly, JWH-030 induced significant changes in the hERG currents, APD, and heart function.
Synthetic cannabinoid, JWH-030, induces QT ... - RSC Publishing
Sep 7, 2016 · The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed that JWH-030 was more cytotoxic than JWH-210, JWH-250, and RCS4 in H9c2 cells at 0.1 μM. In addition, the cytotoxicity was associated with its pro-apoptotic effects as evidenced by the increase in caspase-3 levels.
Assessment of the Abuse Liability of Synthetic Cannabinoid Agonists JWH ...
Nov 1, 2015 · Results showed that JWH-175 (0.5 mg/kg), but not JWH-030 or JWH-176 at any dose, significantly decreased the locomotor activity of mice. This alteration in locomotor activity was only evident during acute exposure to the drug and was not observed during repeated treatment and abstinence.
JWH 030 is a naphthoyl pyrrole cannabimimetic with specificity for the central cannabinoid (CB 1) receptor (EC 50 = 30.5 nM for rat and K i = 87 nM for mouse) over the peripheral CB 2 receptor (EC 50 = 552 nM for human CB2).1,2 JWH 030 2-naphthoyl isomer differs from JWH 030 by having the naphthoyl group
Synthetic cannabinoids: Analysis and metabolites - ScienceDirect
Feb 27, 2014 · Two new synthetic cannabinoids namely JWH-030 and JWH-307 (Fig. 14) were identified by Uchiyama et al. (2013) using UPLC/ESIMS in a methanolic extract of an illegal Japanese herbal product.
Synthetic cannabinoids and potential cardiac arrhythmia risk: …
Mar 24, 2020 · Virtually all drugs that produce acquired long QT syndrome and TdP arrhythmia produce pharmacological inhibition of cardiac ‘hERG’ potassium channels. 10 The SCRA JWH-030 has been reported to inhibit hERG channel current (I hERG), but with relatively low affinity (IC 50 of 88 µM). 13 The compound abbreviated rather than lengthened rabbit ...
Substance Details JWH-030 - United Nations Office on Drugs and Crime
Names: JWH-030 Naphthalen-1-yl-(1-pentylpyrrol- 3-yl)methanone: IUPAC name:: naphthalen-1-yl(1-pentyl-1H-pyrrol-3-yl)methanone Substance group: