Activated T cell-derived exosomal PD-1 attenuates PD-L1 ... - Nature
WEBJun 25, 2021 · As represented by IL-2 levels, the suppression of PBMC-T cell activity was significantly rescued by exosomes from the MB-231-PD-L1: Jurkat-PD-1 co-culture group, which contained Exo-PD-L1:...
PD-L1 expression levels on tumor cells affect their …
WEBSep 20, 2019 · Blocking PD-1/PD-L1 interaction with A0-L, a PD-1/PD-L1 inhibitor, significantly restored the activation of Jurkat cells and the secretion of IFN-γ and IL-2 from PBMC cells, which were significantly inhibited by MCF-7 and MDA-MB-231 cells.
PDL1 targeting by miR-138-5p amplifies anti-tumor immunity and Jurkat …
WEBJun 12, 2024 · The present study aims to impair PD-L1 (B7-H1) expression in Adenocarcinoma cell lines using miR-138-5p and determines how it prevents Jurak cell exhaustion.
PD-1 signaling negatively regulates the common cytokine
WEBNov 6, 2023 · PD-L1 stimulation did not affect the half-life of MARCH5 in CHX-treated Jurkat-PD-1 cells (Fig. 4b), suggesting that PD-1 ligation does not affect its stability.
Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation …
WEBOct 1, 2020 · For the reporter-based assays, Jurkat cells expressing PD-1 and NFAT reporter were cocultured with PD-L1 or dual PD-L1 + PD-L2 stable expressing CHO cells in the presence of LY3434172, each individual parent antibody, or their combination; NFAT reporter expression increased significantly in response …
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in
WEBJul 10, 2018 · Remarkably, preincubation of the PD-1 blockade antibody pembrolizumab with PD-1+/PD-L1+ Raji significantly enhanced the synaptic enrichment of Jurkat PD-1 and Raji PD-L1 (Figures 7B and 7E), suggesting that blockade of APC-intrinsic PD-1 frees up PD-L1 for engaging T cell intrinsic PD-1.
PD-L1: PD-1 Interaction Contributes to the Functional …
WEBTo test whether uveal melanoma expression of PD-L1 affects T-cell function, we cocultured Jurkat T cells with IFN-γ-pretreated OCM1 cells at different E:T ratios for 48 hours and assessed by ELISA their production of IL-2.
Transmembrane domain–driven PD-1 dimers mediate T cell …
WEBMar 8, 2024 · To determine the role of PD-1 dimerization in this process, we used Jurkat T cells and a supported, planar lipid bilayer that incorporated intercellular adhesion molecule–1 (ICAM-1), anti-CD3 Fab, and PD-L1 to mimic an APC.
The Immunostimulative Effect and Mechanisms of a Novel Mouse …
WEBThis suggests that the immune reaction by blocking PD-1/PD-L1 pathway with anti-PD-1 mAb B1C4 restores the function of Jurkat T cells. PD-L1 expressed on tumor cells …
Jurkat T cells increase PD-1/PD-L1-mediated drug
WEBPD-L1 not only serves as an immune checkpoint inhibitor, but also promotes chemoresistance and cell growth, and exerts anti-apoptotic effects on the cancer cells [3,4,37, 38]. However,...
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